Principal Global Health Economic and Outcomes Research Scientist

Neurodegenerative diseases are one of the largest medical challenges of our time. Denali Therapeutics is a biotechnology company dedicated to developing breakthrough therapies for neurodegenerative diseases through our deep commitment to degeneration biology and principles of translational medicine. Denali is founded on the collaboration of leading scientists, industry experts, and investors who share the vision that scientific discovery energetically applied to translational medicine is the key to delivering effective therapies to patients.

We invite you to consider an opportunity with Denali to help achieve our goal of delivering meaningful therapeutics to patients.

This role will be responsible for the development and communication of evidence to support product value, including health economic and real-world evidence (RWE), and dissemination of evidence to support healthcare decision-making. This role will initially focus on support for the rare disease pipeline. Reporting to the Director, Clinical Outcomes this role requires effective cross-functional collaboration with clinical development, medical affairs, marketing, market access and field teams.

Key Accountabilities/Core Job Responsibilities:

• Develop and execute global HEOR strategic plans that reflect input of key stakeholders and are aligned with commercial, clinical, medical, RWE, and market access plans

• Design and execute HEOR projects, including economic modeling, real world evidence, clinical outcomes assessment, indirect treatment comparisons and systematic reviews and other research as needed to support product value proposition 

• Develop HEOR dissemination strategy in alignment with the overall product communication strategy, including timely publication of abstracts and manuscripts and presentations at scientific congresses 

• Synthesize health care economic evidence to support global value dossier and AMCP dossier development

• Provide key input to the design of clinical development programs to ensure appropriate inclusion of design elements and endpoints relevant to payers, clinicians and patients

• Collaborate cross-functionally with access, medical, biometrics, commercial, operations and clinical development functions to ensure integration of HEOR plans within the broader strategic framework

• Develop economic models and healthcare economic information (HCEI) and train the field team for effective communication with population-based decision makers

• Manage HEOR vendors and consultants to provide deliverables in alignment with timelines and objectives

Qualifications/Skills:

• Advanced graduate degree (PhD preferred) in a relevant discipline such as health services research, economics, epidemiology, or public health

• 10 years of relevant experience including post-doctoral; must include 5 years of HEOR or related experience in the pharmaceutical and/or biotech industry 

• Knowledge of US and global healthcare systems, global HTA requirements, and clinical development, to develop product value proposition, identify evidence gaps and formulate evidence generation and communication strategies

• Excellent research skills in HEOR study design, analysis, and interpretation of data to ensure HEOR activities are scientifically and technically rigorous

• Excellent communication, presentation, collaboration and influencing skills cross internal and external stakeholders in a multiculture environment.

• Proven track record of end-to-end project execution, from concept development through to publication.

• Ability to execute HEOR projects independently with minimum guidance.

 

Preferred Experience:

• Experience leading HEOR strategy development and execution to support a product launch

• Experience in outcomes research in rare and/or neurodegenerative therapeutic areas

Salary Range: $183,000.00 to $219,000.00 .  Compensation for the role will depend on a number of factors, including a candidate’s qualifications, skills, competencies, and experience. Denali offers a competitive total rewards package, which includes a 401k, healthcare coverage, ESPP and a broad range of other benefits. Learn more at https://www.denalitherapeutics.com/careers

This compensation and benefits information is based on Denali’s good faith estimate as of the date of publication and may be modified in the future.This compensation and benefits information is based on Denali’s good faith estimate as of the date of publication and may be modified in the future.
 

Denali is committed to its core company value of unity by creating a diverse and inclusive environment. We are proud to be an equal opportunity employer and do not discriminate against any employee or applicant for employment because of race, color, sex, age, national origin, religion, sexual orientation, gender identity and/or expression, status as a veteran, basis of disability, or any other federal, state, or local protected class.

Salary : $183,000 - $219,000