Senior Principal Scientist, Computational Chemistry, ADC Chemistry

We’re in relentless pursuit of breakthroughs that change patients’ lives. We innovate every day to make the world a healthier place.To fully realize Pfizer’s purpose – Breakthroughs that change patients’ lives – we have established a clear set of expectations regarding “what” we need to achieve for patients and “how” we will go about achieving those goals.The ADC (Antibody Drug Conjugate) Chemistry group is seeking a highly motivated, creative, and experienced computational chemist with a proven track record of success in drug discovery, to develop novel payloads and linkers for antibody-drug conjugates (ADCs).You will apply your background in drug development, medicinal chemistry, and computational chemistry to develop new anticancer therapies. Your background in structure-based drug discovery is critical for this position. You will work collaboratively within the chemistry department and researchers across the biology and translational sciences.The successful candidate will be responsible for identifying key opportunities for computational chemistry to impact drug discovery at all stages ranging from target evaluation to hit identification to lead optimization and candidate selection. You will also utilize your computational chemistry and scientific programming expertise to identify methods that can address key challenges and impact drug discovery across the portfolio.ROLE RESPONSIBILITIES : Structure Based Drug Design(SBDD) and conformational analysis to optimize potency and physico-chemical properties of payloads and payloads-linkers.Impact drug discovery projects by identifying the highest impact computational chemistry approaches for specific projects, and developing and delivering timely, high-quality computational solutions.You will : Participate on multiple interdisciplinary project teams and play a key role in defining project strategies.Analyze potential payload targets to assess their druggability and determine the most promising approaches.Design payloads and linkers suitable for ADCs in collaboration with design / synthesis chemists.Apply molecular modeling and dynamics, AI and homology modeling and related techniques to understand biological targets and the mechanisms of payloads.Use both physics-based and AI / ML methods to impact compound design and screening.Bring new computational approaches from within global Computational Chemistry in Pfizer and the literature to speed ADC discovery.Define, implement, and influence project design strategy to deliver projects to key decision points.Influence science at both departmental and external level.Act as an effective mentor for colleagues in the department.BASIC QUALIFICATIONS : PhD in computational chemistry or a related discipline and 5 years of experience in the Biopharmaceutical Industry.Leading-edge knowledge of computational chemistry principles and a track record of successfully applying them to biopharmaceutical research projects.Strong Linux and programming skills.Ability to work in a collaborative environment as exemplified by a strong publication record.PREFERRED QUALIFICATIONS : Significant experience with computational chemistry concepts and techniques.Experience with standard computational chemistry software.Programming and scripting skills (e.g. Python, Linux workflows).Strong working knowledge of related disciplines in drug discovery.ORGANIZATIONAL RELATIONSHIPSWill report to the Head of ADC Chemistry within Oncology Research.Integral part of project teams and work closely with various experts within Pfizer.NON-STANDARD WORK SCHEDULE, TRAVEL OR ENVIRONMENTOccasional travel to Pfizer La Jolla is expected for key interactions.ADDITIONAL INFORMATION : Eligible for Employee ReferralLast Day to Apply : November 15, 2024#J-18808-Ljbffr