Scientist I, Pharmacology

The Scientist I, Pharmacology is responsible for planning, performing, and analyzing the results of scientific experiments that contribute to PTC’s research and drug discovery activities. The incumbent works cross-functionally with internal departments, and external resources as appropriate, as part of PTC’s discovery science project teams. A primary focus of the Scientist I will be identifying and developing new therapies for muscular dystrophy and other neuromuscular diseases.

The Scientist I, Pharmacology supports adherence to relevant regulatory requirements and company Standard Operating Procedures (SOPs) as appropriate.
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• With guidance from the plans and executes scientific research and experiments and interprets and communicates results as part of multi-disciplinary team(s).
• Investigates the feasibility of applying a wide variety of scientific principles and concepts to research problems.
• Presents findings internally to cross-functional teams.
• Abides by all safety and regulatory guidelines.
• Maintains a detailed laboratory notebook.
• Performs other tasks as assigned
• Abides by all safety requirements and IACUC guidelines
• Contributes to general lab needs such as:
  • Equipment maintenance.
  • Capital equipment purchases.
  • Troubleshoot

• Hands on experience with small animals such as rodents including dosing, but may not be limited, performing IV/IP/SC/ICV injections in mice and perform anesthesia and monitor animal health.
• Experience in functional assessment in rodent models of muscular and neuromuscular disease.
• Hands on experience with measuring functional and behavior assays in rodent models of oncology, immunology, or muscular and neuromuscular disease.
• Analysis of biomarkers and histology of muscular regeneration and degeneration parameters. Expertise in IHC very helpful.

• Minimum level of education and years of relevant work experience.

• PhD in relevant discipline, Biology, Neuroscience, Toxicology, Pharmacology, Biochemistry with a minimum of 0-2 years post-doctoral or Industry experience

• Special knowledge or skills needed and/or licenses or certificates required.

• Experience with transgenic mouse model. This include, but may not limited to, colony maintenance, breeding, PCR genotyping, behavioral & functional testing. Demonstrate ability to work on complex problems to produce experimental data across one or more projects.
• Exercises independent judgement within defined procedures and practices.
• Demonstrates technical proficiency, collaboration with others within a fast-paced, matrixed, team environment consisting of internal and external team members.
• Possesses detailed and expert knowledge of scientific principles and concepts.
• Demonstrate ability to work effectively in a multi-disciplinary team environment.
• Experience and proficiency in working with data/statistical analysis software packages such as GraphPad/Prism. Experience and proficiency in working with data/statistical analysis software packages and languages such as R, RStudio, Python, Pandas helpful.
• Proficiency with Microsoft Office preferably MS Excel and MS PowerPoint or similar
• Excellent verbal and written communication and skills.
• Analytical thinker with excellent problem-solving skills.
• Demonstrates an understanding of the strategic alignment of his/her work with corporate goal(s) and demonstrates the ability to adapt to changing priorities and deadlines.
• Excellent planning, organization and time management skills including the ability to support and prioritize multiple projects.

• Special knowledge or skills and/or licenses or certificates preferred.

• Experience in protein quantification end analysis methods such as Western blot, ELISA, MSD and other immunoassays helpful
• Experience in designing and conducting studies in models muscular and neuromuscular diseases.
• Demonstrated knowledge and understanding of rodent and non-rodent models for neurological disease indications, including transgenic and knock-out mice and rats.

• Travel & Physical requirements

• Up to 10%
• Laboratory based position. Must be able to drive to the animal facility and work with rodents.
• Some weekend and/or night work may be necessary