R2.I.07/2024 INVESTIGADOR/A R2.I - R2.I. RESEARCHER (I-81)

We are seeking a highly motivated Postdoctoral Fellow to join the Lipotoxicity and Liver Disease group under the direction of Prof. Antonio Vidal-Puig in collaboration with Dr. Stefania Carobbio at the Centro de Investigación Príncipe Felipe. This role, funded by the Caixa Fundación, will contribute to our research focused on refining the identification of early regulated intrahepatic factors that influence the transition from Metabolic Associated Steatohepatitis (MASLD) to Metabolic Dysfunction-Associated Steatohepatitis (MASH) and evaluate their potential as therapeutic targets and diagnostic/prognostic biomarkers.

The different objectives of the project include both in vivo and in vitro work in the form of:

• Longitudinal exposome-related studies in mice: Several lipid diets, environmental temperature, and GLP1 to define the natural trajectories and potential reversal mechanisms from MASLD to MASH.
• Validation in vitro: Examine the regulation of molecular networks under genetic and environmental stresses using hepatic cellular models.
• In Vivo Validation: Confirm the clinical relevance of identified genes and pathways in the progression of MASLD to MASH through murine and human in vivo studies.

THE CV SHOULD REMOVE ALL PERSONAL REFERENCES: NAME, GENDER, AGE, MARITAL STATUS, NATIONALITY AND SHOULD NOT INCLUDE A PHOTOGRAPH.