88-50101647 Research Associate, Engineering Development (Cell Therapy)

The Position Genentech, Inc. seeks a Research Associate, Engineering Development (Cell Therapy) in its South San Francisco, California location. Duties: Serve as a researcher within the Individualized Medicines Team in Pharma Cell and Gene Therapy Group (“PTC”), which is responsible for the process development, manufacture and supply of personalized immunotherapies. Provide biological/chemical samples to Quality Control to support release and registration, transfer to manufacturing/production sites for use and storage and prepare for research and development activities. Evaluate biological/chemical equipment and the manufacturing environment in accordance with current Good Manufacturing Practices (cGMP) requirements and Roche corporate standards. Utilize sequencing platforms such as Oxford Nanopore for DNA assembly, cloning, screening, and sequencing. Perform and test process development experiments such as E.coli fermentation and lysate preparation to generate material for downstream plasmid purification. Research and analyze current scientific and industry trends in the field of gene therapy development. Implement new technology tools and instrumentation to optimize manufacturing and production operations. Support plasmid manufacturing for novel individualized cell therapies. Provide technical support to cell therapy process development teams in optimization of the cell therapy manufacturing process. Education and experience required: Bachelor’s degree in Biology or closely related field and 5 years of progressive, post-baccalaureate experience as Research Associate, Scientist, or related role. Special Requirements: Must have 5 years of experience with each of the following: Design and modify construct to optimize protein expression in different types of host cells including E. Coli, yeast, insect cell and mammalian cell; Express, extract and purify target proteins across different host cell types; Evaluate target protein expression level, purity, stability and aggregation by SDS-PAGE, FPLC, HPLC, Western Blot; Molecular Cloning of plasmids from primer design to PCR, Gibson assembly, transformation, colony screening to verification of sequence. Must have 3 years of experience with each of the following: Human primary T cell isolation and culture, lentiviral transduction, cell sorting and cytotoxicity assay (in-vitro killing assay); Flow cytometry for analysis of cell therapy product: panel design and flow analysis for testing activation state, phenotype of CAR T cell. May telecommute up to 2 days per week. Worksite: 1 DNA Way, South San Francisco, California, 94080. The expected salary range for this position based on the primary location for this position of California is $114,408 to $143,400 per year. Actual pay within the range will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below. Benefits (https://roche.ehr.com/default.ashx?CLASSNAME=splash) Who we are A member of the Roche Group, Genentech has been at the forefront of the biotechnology industry for more than 40 years, using human genetic information to develop novel medicines for serious and life-threatening diseases. Genentech has multiple therapies on the market for cancer & other serious illnesses. Please take this opportunity to learn about Genentech where we believe that our employees are our most important asset & are dedicated to remaining a great place to work. Diversity and Inclusion (D&I) are critical to the success of our company and our impact on society. We believe that by championing diversity of background, thought and experience, we can foster a sense of belonging and provide an environment where every employee feels valued, included, and able to contribute their best for the patients we serve. We’re focused on attracting, retaining, developing and advancing our people to their full potential by rewarding bold ways of thinking and integrating inclusive behaviors into every aspect of our work. Genentech is an equal opportunity employer, and we embrace the increasingly diverse world around us. Genentech prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity or expression, national origin or ancestry, age, disability, marital status and veteran status. For more information about equal employment opportunity, visit our Genentech Careers Homepage. If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants. We believe it’s urgent to deliver medical solutions right now – even as we develop innovations for the future. We are passionate about transforming patients’ lives. We are courageous in both decision and action. And we believe that good business means a better world. That is why we come to work each day. We commit ourselves to scientific rigour, unassailable ethics, and access to medical innovations for all. We do this today to build a better tomorrow. We are proud of who we are, what we do, and how we do it. We are many, working as one across functions, across companies, and across the world. We are Roche.

Salary : $114,408 - $143,400