Senior Scientist, Biology

 About Us

·       Our team is dedicated to the development of a broad pipeline of small molecules powered by unique chemistry insights to address a wide range of high unmet clinical needs.

·       Our company was created within 5AM Ventures' 4:59 Initiative in 2023.  We are based in Watertown, MA with brand new, custom lab and office space underway!

• You will be integrated into a cross-functional drug discovery team where you will be a key contributor in our early research programs
• You will directly contribute to and complement our existing technical expertise in biochemical and cellular assay development to enhance and accelerate research, as well as foster a collaborative and innovative environment.
• Successfully develop biochemical and cellular assays for compound screening and mechanism of action studies.
• Effectively manage external partnersfor assay development and compound testing.
• Serve as a functional lead for projects and identify critical experiments that will assist in achieving key milestones.
• Partner with Chemistry and other function areas to ensure robust data set to enable rapid decisions and clear and concise presentations across the company and external partners.
• Contribute to new target identification and validation through detailed evaluation of published biology, biochemistry, biophysics, and structural biology information.

• You have spent at least 5 years gaining industry experience in pharma and/or biotech, operating in a multidisciplinary drug discovery team environment.
• You earned your Ph.D in a life science-related discipline  and have at least 5 years experience in pharma and/or biotech conducting assay development, biophysics, and/or enzymology.
• You know drug discovery is a team sport. You’re a collaborative colleague and can work effectively in cross-functional team setting.
• Extensive experience working with a wide range of CRO partners in varied areas of assay development is required.
• Skilled in rigorous data analysis, results presentation, data documentation, and scientific communication.
• Strong track record of in vitro biochemical assay development and familiarity with various assay formats such as fluorescence, luminescence, TR-FRET, AlphaLISA, etc.
• Working knowledge of cell-based assay development and appropriate assay technologies is preferred
• Experience in mechanistic enzymology and biophysical methods such as SPR, MST, ITC, DSF, NMR is preferred
• Demonstrated ability to troubleshoot and optimize experiments
• Your colleagues would describe you as an open and articulate communicator.
• You bring an openness to learn from diverse perspectives and collaborate on multidisciplinary teams.
• You have a track record of scientific vigor and creativity in carrying out research
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• PS – Have you spent time on cell line development, molecular biology, protein expression, purification, 384 well assay development?  We’d really love to talk to you!

We are an equal opportunity employer. We do not discriminate in regard to race, color, religion, national origin, age, sex, sexual orientation, gender identity, marital status, ancestry, physical or mental disability, veteran status, or any other legally protected characteristics.