Job Title: Bioconjugation Process Development Scientist

Job Description

The Temporary Bioconjugation (ADC) Process Development Scientist will have an opportunity to contribute to the company's Antibody Drug Conjugates (ADCs) technology platforms. The successful candidate will be responsible for developing scalable and robust downstream ADC processes and supporting technology transfer efforts, leading to clinical GMP manufacturing of ADCs.

Responsibilities

• Design, execute, and interpret experiments related to the development, optimization, and scale-up of biologics with a focus on ADC Bioconjugation and Purification processes.
• Develop Subject Matter Expertise in bioconjugation (ADC) process development and manufacturing in support of CMC activities.
• Work closely with the research function to understand relevant conjugation chemistries and transition bioconjugation processes from research to CMC activities.
• Identify, evaluate, and implement new and existing technologies to improve process efficiency, control, and understanding.
• Apply DOE and other advanced statistical techniques to design experiments related to process development.
• Author high-quality documents, including technical reports, SOPs, experimental protocols, tech transfer documents, batch records, and sampling plans.
• Contribute to manufacturing floor activities and provide scale-up, technical support, and troubleshooting to manufacturing groups at clinical and commercial sites.
• Work effectively with CDMOs.
• Familiarity with analytical, formulation, and general CMC scope for biologics is preferred.

Essential Skills

• Bachelor’s degree in chemistry, biochemistry, pharmaceutical sciences, chemical engineering or related field with a minimum of 5 years of relevant industry experience; or,
• Master’s degree in chemistry, biochemistry, pharmaceutical sciences, chemical engineering or related field with a minimum of 3 years of relevant industry experience; or,
• Equivalent combination of education and experience.
• Direct experience in designing and implementing experiments to evaluate bioconjugation processes, including ADCs.
• Hands-on experience with ADC chemistry, reaction processes, and purification methods (e.g., Tangential Flow Filtration, chromatography).
• Experience and working knowledge of technical transfer for Biologics manufacturing (bioconjugations).

Additional Skills & Qualifications

• Additional experience with the development and manufacturing of mAbs, bispecifics, and/or linker-toxins used in ADC production.
• Familiarity with analytical methods.
• Ability to collaborate with cross-functional teams, both internally and with external CDMOs and partners.
• Ability to multi-task in a fast-paced dynamic environment while delivering high-quality work.
• Self-motivated, accountable, and inquisitive attitude with excellent interpersonal, presentation, and written communication skills.
• Creative thinker and complex problem solver with strong attention to detail.

Work Environment

The work environment includes regular shifts from 8 AM to 5 PM, primarily working in laboratories or in office settings. The role may involve exposures to hazardous materials and extreme cold. Limited travel is required.

Pay and Benefits

The pay range for this position is $60.00 - $75.00/hr.

Eligibility requirements apply to some benefits and may depend on your job classification and length of employment. Benefits are subject to change and may be subject to specific elections, plan, or program terms. If eligible, the benefits available for this temporary role may include the following:

• Medical, dental & vision
• Critical Illness, Accident, and Hospital
• 401(k) Retirement Plan – Pre-tax and Roth post-tax contributions available
• Life Insurance (Voluntary Life & AD&D for the employee and dependents)
• Short and long-term disability
• Health Spending Account (HSA)
• Transportation benefits
• Employee Assistance Program
• Time Off/Leave (PTO, Vacation or Sick Leave)

Workplace Type

This is a fully onsite position in Alameda,CA.

Application Deadline

This position is anticipated to close on Feb 11, 2025.

About Actalent

Actalent is a global leader in engineering and sciences services and talent solutions. We help visionary companies advance their engineering and science initiatives through access to specialized experts who drive scale, innovation and speed to market. With a network of almost 30,000 consultants and more than 4,500 clients across the U.S., Canada, Asia and Europe, Actalent serves many of the Fortune 500.

Diversity, Equity & Inclusion

At Actalent, diversity and inclusion are a bridge towards the equity and success of our people. DE&I are embedded into our culture through:

• Hiring diverse talent
• Maintaining an inclusive environment through persistent self-reflection
• Building a culture of care, engagement, and recognition with clear outcomes
• Ensuring growth opportunities for our people

The company is an equal opportunity employer and will consider all applications without regard to race, sex, age, color, religion, national origin, veteran status, disability, sexual orientation, gender identity, genetic information or any characteristic protected by law.

If you would like to request a reasonable accommodation, such as the modification or adjustment of the job application process or interviewing process due to a disability, please email actalentaccommodation@actalentservices.com for other accommodation options.

Salary : $60 - $75