What are the responsibilities and job description for the Principal Scientist / Associate Director, Bioanalytical Assays position at Addition Therapeutics?
Company
Addition Therapeutics is at the forefront of biotechnology innovation, advancing transformative therapies utilizing its proprietary PRINT™ (Precise RNA-mediated Insertion of Transgenes) platform. PRINT™ redefines genetic medicine by enabling development of RNA-only therapeutics capable of inserting any genetic element into specific safe harbor sites within the genome. Operating from state-of-the-art labs in South San Francisco, our team of experienced scientists and drug developers is leading scientific breakthroughs while cultivating a vibrant, dynamic culture committed to profoundly impacting patient lives.
What You Will Do
Addition Therapeutics is seeking a highly skilled and motivated Principal Scientist / Associate Director to join our dynamic Preclinical Translation Team, focused on advancing our novel PRINT™ platform to the clinic. The successful candidate will lead our bioanalytical efforts to assess the efficacy and safety of the PRINT RNA-based payloads for treatment of genetic liver diseases. The incumbent will lead the development, validation, and execution of a variety of protein and cell-based metabolic and enzymatic assays to advance our therapeutic programs from the initial in vitro and in vivo proof of concept to IND-enabling studies. A really strong Bioanalytical / Biochemistry background, preferably in enzymology and liver metabolic diseases, is required for this position. The ideal candidate will possess relevant experience in pre-clinical drug discovery of nucleic acid-based therapeutics. They will be a highly collaborative and resourceful scientist with superior communication skills who can work on multiple projects in a fast-paced, matrixed setting. This role has vast learning opportunities in the field of permanent gene insertion into the genome and presents a unique opportunity to explore the multifaceted applications of PRINT™, paving the way for novel therapeutic avenues/novel therapeutic programs and potential partnerships that could redefine the landscape of genetic medicine.
Key Responsibilities
The expected annual salary range for this full-time position is $187,000 - $212,000 plus eligibility for bonus, benefits, and equity incentives. Actual pay will be determined based on experience, qualifications, business needs, internal equity, and alignment with market data.
We are an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.
Addition Therapeutics is at the forefront of biotechnology innovation, advancing transformative therapies utilizing its proprietary PRINT™ (Precise RNA-mediated Insertion of Transgenes) platform. PRINT™ redefines genetic medicine by enabling development of RNA-only therapeutics capable of inserting any genetic element into specific safe harbor sites within the genome. Operating from state-of-the-art labs in South San Francisco, our team of experienced scientists and drug developers is leading scientific breakthroughs while cultivating a vibrant, dynamic culture committed to profoundly impacting patient lives.
What You Will Do
Addition Therapeutics is seeking a highly skilled and motivated Principal Scientist / Associate Director to join our dynamic Preclinical Translation Team, focused on advancing our novel PRINT™ platform to the clinic. The successful candidate will lead our bioanalytical efforts to assess the efficacy and safety of the PRINT RNA-based payloads for treatment of genetic liver diseases. The incumbent will lead the development, validation, and execution of a variety of protein and cell-based metabolic and enzymatic assays to advance our therapeutic programs from the initial in vitro and in vivo proof of concept to IND-enabling studies. A really strong Bioanalytical / Biochemistry background, preferably in enzymology and liver metabolic diseases, is required for this position. The ideal candidate will possess relevant experience in pre-clinical drug discovery of nucleic acid-based therapeutics. They will be a highly collaborative and resourceful scientist with superior communication skills who can work on multiple projects in a fast-paced, matrixed setting. This role has vast learning opportunities in the field of permanent gene insertion into the genome and presents a unique opportunity to explore the multifaceted applications of PRINT™, paving the way for novel therapeutic avenues/novel therapeutic programs and potential partnerships that could redefine the landscape of genetic medicine.
Key Responsibilities
- Development and hands-on execution of the bioanalytical / biomarker strategy for multiple liver PRINT programs.
- Oversee the development, validation and execution of a variety of enzyme-based metabolic assays and other biomarkers to evaluate the safety and efficacy of our targeted gene insertion.
- Collaborate and align with internal teams and partners to integrate and optimize new assay technologies and methodologies to advance therapeutic programs.
- Manage the work of others directly as well as in a matrixed structure to conduct rigorous science and deliver high quality data in a timely manner.
- Oversee group communication of study results to the project teams and to internal and external stake holders.
- Support evaluation of BD opportunities and patent filling
- Act as a scientific mentor and role model, supporting the Addition Therapeutics culture.
- Potentially oversee the preclinical program strategy and inform key decisions.
- PhD in Biochemistry, Cell or Molecular Biology or a related field with 10 years of relevant experience or BS/MS with 20 years of relevant experience in similar life sciences-related field.
- Expertise in protein quantification and enzymatic assays is required for this role.
- Demonstrated proficiency in advanced analytical techniques such as HPLC and familiarity with Mass Spectrometry.
- Proven track record of developing and executing bioanalytical / biomarker strategies for liver gene therapy programs, ideally in the RNA therapeutics space.
- Familiarity with regulatory requirements and quality standards (FDA, EMA) for bioanalytical testing in the context of gene therapy is a plus.
- Demonstrated ability to independently solve scientific problems using multiple technologies and approaches.
- Experience in developing and working with in vitro and in vivo models for liver diseases.
- Experience in managing direct reports and setting team priorities. Strong leadership and interpersonal skills with a proven track record of leading cross-functional teams is a big plus.
- Team player who fosters a culture of collaboration, accountability, and scientific excellence, and who thrives in a fast-moving, results-oriented startup environment.
- A self-motivated, driven individual with a passion to learn and can-do attitude.
The expected annual salary range for this full-time position is $187,000 - $212,000 plus eligibility for bonus, benefits, and equity incentives. Actual pay will be determined based on experience, qualifications, business needs, internal equity, and alignment with market data.
We are an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.
Salary : $187,000 - $212,000