Senior Research Associate - Mass Spec & Analytical Development - Temporary

Our mission is to develop therapies that empower the immune system to combat neurodegeneration and our team is focused on developing treatments for some of the most challenging diseases facing our society. By harnessing advancements in genetics, immunology and neuroscience, we are pioneering the development of potential therapies to counteract the devastating progression of neurodegeneration. We are supported in this mission by experienced and accomplished scientists and clinicians, a novel portfolio of programs, leading healthcare investors, and pharma company partners, who share in our commitment to bettering the lives of patients and realizing a world where we make brain disorders history.

Use your scientific skills to help us achieve our mission of saving lives by curing neurodegenerative diseases. You will identify and provide support for ongoing programs and your work will be central to Alector’s strategic goals. You will be influential in championing and developing Alector’s culture and values.

As a Senior Research Associate, you will be part of an Analytical Development Team and will work closely with Analytical team members and other members of Process Sciences. Communication and dedication are key aspects required in this role. You will have the opportunity to work collaboratively with cross-functional members across multi-discipline departments and multi-levels including cell culture, upstream, purification, discovery, pre-clinical, and research.

Alector is seeking a candidate with hands-on experience in protein characterization and protein formulation stability. The successful candidate should have a strong scientific foundation and be experienced with mass spectrometry operations and methodologies as well as be familiar with various chromatography methods such as Affinity, SEC, IEX, HIC, RP-HPLC and other analytical techniques such as ELISA, CE-IEF and CE-SDS.

• Perform analytical method developments for various leading drug candidates
• Carry out formulation stability studies for new molecules from research to critical reagents and supporting IND filings
• Conduct mass spectrometry experiments of early and late-stage, research biomolecules, internal discovery efforts and phase appropriate IND/BLA filings

• A BS in scientific discipline e.g. chemistry, biochemistry, with 5 years of related experience or an MS in scientific discipline e.g. chemistry, biochemistry, with 2-4 years of related experience
• 1-2 years of hand on experience in mass spectrometry. Plus for Orbitrap and sample preparation for MS
• Hands-on experience in many laboratory analytical techniques including ELISA, CE-IEF, CE-SDS.
• Hands-on experience in chromatography development work including RP, HIC, IEX, SEC and SEC-MALS.
• Demonstrated ability to design, execute and analyze experiments independently.
• Able to follow protocols and test methods.
• A team player, willing to work together, and share knowledge and work accomplishments.
• Strong and effective interpersonal skills with managers, peers, and cross-functional groups.
• Thrive and foster a culture of open communication and trust
• Strong organizational skills and strong attention to detail
• Ability to prioritize work to support drug development and meet deadlines and timeframes.
• Effective work ethic and dedication to completing challenging projects.
• Strong problem-solving capabilities.
• Authored or co-author various technical documents, including Comparability Studies, GLP Studies, and Qualification Studies is a plus.
• Prepared and presented scientific findings at internal/departmental meetings

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At Alector, our vision is bold, people are our priority, and our values are at the core of everything we do. Our dynamic and flexible environment encourages our teams to experiment, take ownership of decisions, and question convention to solve complex problems. We value shared wins, perseverance, and a growth mindset, which drives us forward, together.  

Among the things you'll discover at Alector from your very first day are our committed and driven colleagues, a bold company vision, and new, modern offices designed to inspire innovation and collaboration in South San Francisco, right at the heart of Biotech Bay. Our benefits are thoughtfully designed around Alectorians and their loved ones and include flexible hybrid work options, competitive compensation, and comprehensive and unique benefits that enhance your health and well-being. Come join us! 

We believe that hard-working teams include people from a wide variety of backgrounds and experiences who can challenge each other’s assumptions with fresh perspectives and bring creative ideas to the table. We are committed to building an open, diverse, and inclusive environment for all employees. We do not discriminate on the basis of race, religion, color, national origin, sex, gender, sexual orientation, age, marital status, veteran status, or disability status, or any other characteristics protected under applicable federal, state, or local laws.  

We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, perform essential job functions, and receive other benefits and privileges of employment. Please contact us to request accommodation. 

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Salary : $40 - $55