Senior Scientist, Antibody Conjugation

We are seeking a Senior Scientist to join our Protein Sciences group to help with our antibody conjugation efforts. The candidate must be independent, goal oriented, technically competent, and able to work efficiently across multiple projects. We are searching for enthusiastic, innovative, and highly motivated individuals, with a scientific background in antibody-drug conjugates including the assembly, purification, and analysis of these molecules.
This position is onsite and will be located at 675 W. Kendall St. Cambridge, MA 02142
This is a laboratory-based position

Key Responsibilities

* Perform chemical reactions to assemble antibody-oligonucleotide conjugates using various conjugation handles, linkers, and antibody formats (IgG, Fab, scFv, bispecific)
* Utilize multiple strategies for site-specific conjugation such as engineered cysteines
* Optimize reactions and purification methods to improve yields ranging from mg to gram scale
* Independently troubleshoot conjugation reactions for improved yields and processes
* Analyze conjugates using all relevant techniques (IEX, HIC, SEC, SDS-PAGE, mass spec,)
* Understanding of antibody design and cloning is nice to have
* Understanding of antibody ligand/target validation using BLI and SPR for kinetic analysis is nice to have
* Work closely with biology teams to plan studies and generate materials on time for multiple projects
* Proper electronic notebook record keeping with high attention to detail
* Communication of experimental plans and data to multiple cross-functional scientific teams
* Work closely with biologists, chemists, and pharmacologists to contribute to the strategic direction of research programs across multiple therapeutic modalities

Qualifications

* The candidate should have a PhD degree with 3 years of relevant experience, BS/MS with 8 years of relevant experience
* Strong understanding of antibody conjugation chemistries such as engineered cysteine, enzymatic, and other site-specific techniques
* Strong understanding of antibody-drug payloads and linkers with oligonucleotide conjugates being preferred
* Hands on experiences with preparing antibody-drug conjugates and analyzing them using multiple methods (IEX, HIC, SEC, mass spec)
* 3 years of pharmaceutical or biotechnology industry experience is preferred
* Experience with AKTA and unicorn software
* Experience with recombinant protein analysis (affinity, size exclusion, reverse phase, hydrophobic interaction, ion exchange chromatography, SDS-PAGE, and UV-VIS spectroscopy)
* Experience with SPR and/or Octet binding experiments is nice to have
* Passionate about driving his or her projects to independently contribute to research directions and solve challenging issues
* Detail oriented, self-motivated, and comfortable working with highly technical projects
* Ability to work on multiple projects simultaneously and deliver conclusive results
* Highly adaptable and responsive to new priorities in a fast passed environment
* Effective written and oral communication skills
* Experience with ELN recording keeping
* Team oriented with strong work ethic

About Alnylam:Alnylam Pharmaceuticals (Nasdaq: ALNY) has led the translation of RNA interference (RNAi) into a whole new class of innovative medicines with the potential to transform the lives of people afflicted with rare and more prevalent diseases. Based on Nobel Prize-winning science, RNAi therapeutics represent a powerful, clinically validated approach to treating diseases at their genetic source by "interfering" with mRNA that cause or contribute to disease. Since our founding in 2002, Alnylam has led the RNAi Revolution and continues to turn scientific possibility into reality.

Our culture:Our people-first culture is guided by our core values: fiercely innovative, open culture, purposeful urgency, passion for excellence, and commitment to people, and these values influence how we work and the business decisions we make. Thanks to feedback from our employees over the years, we've been fortunate to be named a top employer around the world. Alnylam is extremely proud to have been recognized as one of Science Magazine's Top Biopharma Employers, one of America's Most Responsible Companies for 2024 by Newsweek, a Fast Company Best Workplace for Innovators, and a Great Place to Work in Canada, France, Italy, Spain, Switzerland, and UK - among others.

At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. We are dedicated to building an environment where employees can feel that they belong, can bring their authentic selves to work, and achieve to their full potential. By empowering employees to embrace their unique differences at work, our business grows stronger with advanced and original thinking, allowing us to bring groundbreaking medicines to patients.