What are the responsibilities and job description for the AAV Production Senior Research Associate / Associate Scientist position at Amber Bio?
Amber Bio is a biotechnology company pioneering new gene editing modalities using multi-kilobase edits to reach previously undruggable patient populations. Founded by pioneers in the CRISPR field from leading institutions for gene editing research, the company is developing a first-of-its-kind RNA writing platform that can correct thousands of bases at once, thereby correcting genetic mutations safely and reversibly. Multiple openings are available on a rapidly growing team. As an early team member, you will have the opportunity to contribute to strategic planning and future hiring. If you are interested in building a new frontier in genetic medicine, please apply via LinkedIn or through our website ( ).
We are seeking a skilled AAV Production Senior Research Associate / Associate Scientist to join our growing team. This role involves leading and executing all aspects of AAV production, with a focus on downstream optimization to enhance viral yield, quality, and consistency. The ideal candidate will bring extensive expertise in AAV production across adherent and suspension cell platforms and demonstrate a proven track record of optimizing protocols for scale-up, purification, and workflow efficiency. This role requires a collaborative spirit and the ability to work across teams to support AAV production and characterization.
Key Responsibilities
AAV Production and Process Development
- Develop and scale AAV production processes, including IOX gradient purification and affinity column purification, for increased yield and optimized turnaround.
- Perform cell culture for AAV production (adherent and suspension).
- Operate bioreactors, AKTA systems, pumps, mixers, and automated buffer exchange systems to streamline and automate purification workflows.
- Continuously improve purification methods (e.g., AKTA tandem purification) to automate and streamline multi-sample processes.
AAV Characterization and Assay Development
Inventory, Documentation, and Workflow Management
Collaboration and Training
Qualifications
Preference will be given to those who display :
If you have a passion for advancing gene editing technologies and desire to be part of a pioneering biotech company, we encourage you to apply and join our ambitious team.
Please apply directly through LinkedIn or through our website ( ).
Amber Bio is an equal-opportunity employer and encourages applications from candidates of diverse backgrounds. We value diversity and are committed to creating an inclusive and supportive work environment for all employees.
