What are the responsibilities and job description for the Small Molecule Drug Substance Development and Manufacturing Intern position at Arcus Biosciences?
Arcus Biosciences focuses on development of combination immuno-oncology therapeutics using both small molecules and monoclonal antibodies. The Small Molecule Drug Substance Development and Manufacturing group plays the key role of developing efficient synthetic chemical processes for the manufacturing of active pharmaceutical ingredients (APIs or Drug Substances).
The summer intern will work under the supervision of experienced team member(s) to carry out tasks related to the evaluation of synthetic organic reactions related to the drug substance process development, that can be in the content of route exploration or process optimization.
Responsibilities
• Plan and execute organic reactions, gather relevant data, leveraging state-of-the-art technology such as NMR, HPLC, LCMS, and interpretate the results.
• Communicate the results in written reports and at times present the results in group settings.
• Contribute to the team effort in developing efficient, innovative synthetic processes for new drug substances that are potentially part of scientific journal publications.
Qualifications
• Currently enrolled as full-time graduate student pursuing either MS degree or PhD degree in Organic Chemistry. Preferably the candidate has completed core course requirements for MS or PhD degree and ready to start graduate level research. The candidate has had at least one semester research experience that is focused on experimental work in chemistry lab.
• Fully familiar with common analytical and separation techniques such as flash column chromatography, NMR, HPLC and LCMS.
• Proficient in required software including Microsoft Office Suite (Word, Excel, PowerPoint, Outlook) and ChemDraw.
PHYSICAL REQUIREMENTS: • Frequently stand, walk, twist, bend, stoop, squat, grasp lightly, use fine manipulation, grasp forcefully, perform desk-based computer tasks, use telephone, write by hand, lift, carry, push and pull objects weighing over 40 pounds. • Occasionally sit, kneel, crawl, reach and work above shoulders, sort and file paperwork or parts. • Rarely climb, scrub, sweep, mop, chop and mix or operate hand and foot controls. • Must have correctible vision to perform duties of the job. • Ability to bend, squat, kneel, stand, reach above shoulder level, and move on hard surfaces for up to eight hours. • Ability to lift heavy objects, possibly weighing up to 50 pounds. • Position may require repetitive motion. WORKING CONDITIONS: • May require working near blood borne pathogens. • May require work in an environment where animals are used for teaching and research. • Position may at times require the employee to work with or be in areas where hazardous materials and/or infectious diseases are present. • Employee must perform tasks that require the use of personal protective equipment, such as safety glasses and shoes, protective clothing and gloves, and possibly a respirator. • May require extended or unusual work hours based on research requirements and business needs. *Consistent with its obligations under the law, the company will provide reasonable accommodation to any employee with a disability who requires accommodation to perform the essential functions of his or her job.
• All applicants must be actively enrolled in an accredited academic program for Fall
2025.
• As an Arcus intern, you will be employed as a temporary hourly employee.
• Intern will be paid $30 - $45 per hour (depending on education) less payroll deductions and all required tax withholdings.
Salary : $30 - $45
