Director Medical Value, Evidence, and Outcomes

Arrowhead Pharmaceuticals, Inc. (Nasdaq: ARWR) is a clinical stage biopharmaceutical company that develops medicines that treat intractable diseases by silencing the genes that cause them. Using a broad portfolio of RNA chemistries and efficient modes of delivery, Arrowhead therapies trigger the RNA interference mechanism to induce rapid, deep, and durable knockdown of target genes. RNA interference, or RNAi, is a mechanism present in living cells that inhibits the expression of a specific gene, thereby affecting the production of a specific protein. Arrowhead’s RNAi-based therapeutics leverage this natural pathway of gene silencing.

Arrowhead is focused on developing innovative drugs for diseases with a genetic basis, typically characterized by the overproduction of one or more proteins that are involved with disease. The depth and versatility of our RNAi technologies enables us to potentially address conditions in virtually any therapeutic area and pursue disease targets that are not otherwise addressable by small molecules and biologics. Arrowhead is leading the field in bringing the promise of RNAi to address diseases outside of the liver, and our clinical pipeline includes disease targets in the liver and lung with a promising pipeline of preclinical candidates.

Arrowhead’s corporate headquarters is in Pasadena, CA with research and development teams in Madison, WI and San Diego, CA. Our employees are nimble, science-driven innovators who are collaborating to bring new therapies to patients in need.

The Position

Let’s do something amazing together! The Director of Medical Value, Evidence, and Outcomes (MVEO) will play a pivotal role in the launch of Arrowhead’s leading investigational cardiometabolic molecule – Plozasiran (siRNA targeting APOC3). Plozasiran has demonstrated compelling clinical data to date and is in late-stage development with the potential to treat diseases by silencing causative genes.

The Director of MVEO will be a key member of Arrowhead's Medical Affairs Leadership Team, reporting directly to the Vice President of Medical Affairs. This is a multifaceted role with two key areas of focus. One of the key responsibilities will be to design, implement, manage, and disseminate Medical Real World Evidence. Another important aspect of the role is to partner with Market Access and engage payers with medically focused presentations. Additional cross-functional partnerships include Regulatory, Clinical Development, Clinical Development, Biometrics, and Commercial teams, to effectively develop and disseminate data in support of the development and commercialization of our cardiometabolic assets.

This role is based in Pasadena, California, with an expectation to be in office 5 days a week.

Responsibilities

• Develop and execute the Real World Evidence (RWE) generation strategy for Arrowhead’s cardiometabolic pipeline to inform value proposition from both a medical and payer perspective.
• Develop and review economic resources, including cost-effectiveness models, to support value proposition. Integrate research findings into payer communication materials.
• Develop publications and external communications based on real world evidence generation, partnering closely with the publications lead.
• Educate payers by delivering impactful scientific and economic data presentations.
• Collaborate with commercial team members to align payer positioning and messaging with outcome-based evidence. Share expertise as a trusted partner and resource.
• Effectively manage consultants and vendors.
• Review clinical development plans, including trial design, endpoints, and analytical strategies, to provide feedback and ensure alignment with payer needs.
• Attend medical, pharmacy, and payer professional meetings to stay current and ensure expertise with industry trends and new research affecting Familial Chylomicronemia Syndrome (FCS), Severe Hypertriglyceridemia (SHTG), and Mixed Hyperlipidemia.
• Conduct horizon scanning and maintain literature awareness to identify and evaluate scientific gaps and opportunities in the cardiometabolic space.
• Stay informed about current advancements and new developments in RNA interference.
  
  

Requirements:

• Advanced degree in health economics, health outcomes research, or a related field (MSc, MPH, PhD, PharmD, MD).
• At least five years of relevant experience in health economics, outcomes research, pricing, reimbursement, medical affairs, and/or portfolio analysis.
• Experience in cardiometabolic therapeutic area, preferably with a focus on dyslipidemias.
• Ability to clearly communicate complex scientific and medical concepts, both written and orally; detail-oriented and data-driven.
• Ensure compliance with corporate policies, procedures, and US healthcare laws and regulations.
• Ability to work collaboratively in a matrixed, team-based environment, with strong organizational and time management capabilities.
• Exceptional project management skills, ensuring on-time and budget-compliant deliverables.
• Passionate in working in a fast-paced, team-based environment.
  
  

California pay range

$210,000—$240,000 USD

Arrowhead provides competitive salaries and an excellent benefit package.

All applicants must have authorization to work in the US for a company.

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