Summer Intern, CMC Process Development

Arrowhead Pharmaceuticals, Inc. (Nasdaq: ARWR) is a clinical stage biopharmaceutical company that develops medicines that treat intractable diseases by silencing the genes that cause them. Using a broad portfolio of RNA chemistries and efficient modes of delivery, Arrowhead therapies trigger the RNA interference mechanism to induce rapid, deep, and durable knockdown of target genes. RNA interference, or RNAi, is a mechanism present in living cells that inhibits the expression of a specific gene, thereby affecting the production of a specific protein. Arrowhead’s RNAi-based therapeutics leverage this natural pathway of gene silencing.

Arrowhead is focused on developing innovative drugs for diseases with a genetic basis, typically characterized by the overproduction of one or more proteins that are involved with disease. The depth and versatility of our RNAi technologies enables us to potentially address conditions in virtually any therapeutic area and pursue disease targets that are not otherwise addressable by small molecules and biologics. Arrowhead is leading the field in bringing the promise of RNAi to address diseases outside of the liver, and our clinical pipeline includes disease targets in the liver and lung with a promising pipeline of preclinical candidates.

Arrowhead’s corporate headquarters is in Pasadena, CA with research and development teams in Madison, WI and San Diego, CA. Our employees are nimble, science-driven innovators who are collaborating to bring new therapies to patients in need.

The Position

Join our CMC Process Development Team as an intern and gain hands-on experience in developing scalable synthetic processes. This project focuses on optimizing reaction conditions, purification, and isolation techniques to improve efficiency and flexibility in material production. You will explore alternative synthetic routes, enhance process safety, and contribute to expanding in-house capabilities. Your work will provide valuable insights into reaction optimization, material modifications, and scale-up strategies, supporting broader research and development initiatives. This internship offers a unique opportunity to apply synthetic chemistry principles in a dynamic, innovation-driven environment.

This is a 12 week Summer Internship Program paying $19.00/hr.

Responsibilities

• Collaborate with scientists to develop and optimize reaction conditions for multi-step synthetic routes
• Perform synthesis, isolation, purification, and characterization of small molecules, focusing on developing robust and scalable procedures
• Analyze small-molecule compounds using standard analytical techniques such as NMR, HPLC, and mass spectrometry
• Maintain a detailed and well-documented laboratory notebook to record experimental data and observations
• Present research findings and progress to team members during group meetings at the conclusion of the internship
  
  

Requirements:

• Currently enrolled student at an Accredited University or College and majoring in, Chemistry, Chemical Engineering, or related area of study
• Completion of at least one semester of organic chemistry and one semester of organic chemistry lab.
• Excellent verbal and written communication skills
• Strong problem-solving skills
• Eagerness to learn new techniques
• Ability to work in a lab setting for prolonged periods of time
• Ability to wear personal protective equipment as required
• Must be able to lift 15 pounds at a time
  
  

Preferred:

• Student entering junior or senior year of undergraduate study.
• Prior research experience in an academic or industrial setting, preferably in organic synthesis or medicinal chemistry.
• Experience with analytical techniques such as NMR, HPLC, and mass spectrometry.
  
  

Wisconsin pay range

$9,120—$9,120 USD

Arrowhead provides competitive salaries and an excellent benefit package.

All applicants must have authorization to work in the US for a company.

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