What are the responsibilities and job description for the Scientist, Analytical Development (Cell-Based Assays and ELISA) position at Arsenal Biosciences?
WHO WE ARE
Arsenal Biosciences Inc. is a clinical-stage programmable cell therapy company engineering advanced CAR T-cell therapies for solid tumors. We seek a talented and experienced Scientist I to work onsite based in our Hayward office.
ArsenalBio’s mission and purpose are very clear: defeat cancer. With our programmable and computationally driven approach, our team is engineering medicines to attack cancer’s inherent multifaceted nature and overcome the challenges of addressing solid tumors with cell therapy.
Driven by a collective of diverse experts across multi-scientific disciplines and clinical and manufacturing expertise, we are united in our purpose to develop the optimal medicines for improving patients’ lives.
This means you’ll have the opportunity to work with the best talent in the field of cell therapy and be part of ONE TEAM, which advances therapies for patients who need it most.
We are seeking a talented and motivated Scientist to join the ArsenalBio Technical Operations team. The individual will work closely with team members to develop analytical test methods and characterization tools in support of our cell therapy products. The individual will also interact cross-functionally across the organization to enable the success of ArsenalBio.
WHAT YOU’LL DO
- Independently design, test, and implement quality-based analytical assays to support the characterization and release of cell therapy products.
- Actively contribute to the development, and efficient execution of analytical methods for characterization of cell therapy process development, process manufacturing and drug products.
- Serve as an analytical SME to develop and perform in vitro cell-based analytical assays (cytotoxicity, cytokine, proliferation, etc.) for cell therapy product development
- Provide analytical support for clinical-scale IND-enabling manufacturing operations including:
- Preparation of test methods, SOPs and technical development reports
- Assay qualification, provide technical support and tech transfer to Quality Control in supporting of QC assay establishment and GMP lot release
- Provide technical expertise and leadership within Analytical Development teams and in a matrix environment
- Establish data tracking and trending analyses of process developmental runs and cGMP production runs, including evaluation of critical reagents and lot to lot variability, in order to improve process and assay standardization
- Good understanding of cGMP environment, and Quality by Design (QBD) principles for assay development, qualification and validation preferred
- Collaborate closely with other functions to enable effective and successful project development; actively engage in cross-functional collaboration with peers to overcome challenges
- Organize, communicate, and present complex data sets to key stakeholders and senior management
- Provide leadership and mentorship to junior SRAs
WHO YOU ARE
- Master’s degree with 5 years of experience, or a Bachelor’s degree with 7 years of experience, in Biotechnology, Bioprocess Engineering, Immunology, Molecular Biology, Biochemistry, or a related field, along with relevant industry experience
- Excellent mammalian cell culture skills
- Experience with immunological assays, such as cytokine/chemokine analysis (ELISA, Luminex or intracellular cytokine staining) and cytotoxicity
- Proficiency using data analysis and interpretation using software such as GraphPad, Excel and JMP
- Experience in technical development of analytical methods to support cell and gene therapy biologics and other advanced modalities in pre-clinical development and clinical stage settings (Phase II experience a plus)
- Ability to learn new skills quickly to advance method development in support of drug product manufacturing
- Strong problem-solving skills, with the ability to anticipate issues and identify solutions
- Demonstrated ability to work as a team player in a collaborative environment and coordinate tasks across multiple projects to meet deadlines
- Ability to lead the development of cell based assays successfully and handle multiple challenges under expedited timelines
- Excellent communications, technical writing, presentation, written and verbal skills
- Excellent organizational skills: Proactive management of multiple tasks of varying complexity simultaneously
- Leadership to raise the level of the team's technical capabilities
- Willingness to accept responsibilities outside of initial job description
BENEFITS AND PAY
ArsenalBio has a generous and comprehensive benefits package that includes but is not limited to medical, dental, and vision as well as mental health resources, virtual and telehealth options, coaching, infertility treatment, parental leave and health savings accounts. We also offer flexible work schedules and flexible time off, which includes two extra “Arsenal Days of Rest” every quarter for employees to recharge.
Our people-first culture fosters a deep appreciation for humanity, both in the people we endeavor to serve as well as each other. We are proud to work for a company that is driven by diversity in experiences, ideas and interests, and one that empowers us in an environment that embraces both unity and inclusivity.
We have robust tools to help employees take control of their career paths and grow into their best selves. ArsenalBio believes in investing in the well-being of our employees - both at work and at home, as our people are our greatest asset. They bring scientific talents in molecular biology, immunology, pharmacology, protein chemistry, computational biology, automation, genome engineering, software and other fields to make the future happen now.
We are committed to hiring the best talent from diverse backgrounds. A diverse workforce engenders richness of thought, creativity and discovery. We invite individuals who embrace intellectual achievement to bring their unique personal and professional journeys and together we will build transformative cell therapies for cancer patients.
We are an equal opportunity employer and value diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.
The estimated base salary for the preferred primary location of the San Francisco Bay area ranges from $113,600–$139,100. Salary ranges for other locations may vary. Base pay offered may vary based on job related knowledge, experience, education, and location. In addition to these factors, we believe in the importance of pay equity and consider internal equity of our current employees as part of any final offer.
To all recruitment agencies: ArsenalBio does not accept agency resumes. Please do not forward resumes to our jobs alias, or ArsenalBio employees. ArsenalBio is not responsible for any fees related to unsolicited resumes.
Bold ideas. Reliable data. World-Class Science.
Designing therapies to cure our most important health challenges requires the audacity to advance a bold idea and explore new biologies with world-class science.
By pushing at the frontiers of science, challenging what we think we know, and holding ourselves to the highest standards of irrefutable proof, we are reshaping the future of curative cellular therapies.
Benefits
ArsenalBio is powered by people.
And we believe that people work best when given freedom and flexibility in a supportive environment that allows us all to show up as our true selves. We respect that your life extends beyond the work we’ll do here together, and we continually strive to provide you with what you need to care for yourself and your family.
Health & Wellness
Financial Well-Being
Time Off
Mindful Workspace
ArsenalBio was formed by its investors and scientific founders to discover, develop and commercialize curative and safe cellular therapies for patients with life threatening diseases, initially cancer.
We believe the most productive and secure route to achieving this goal is to build scaled platforms of technologies challenged with scientific questions to yield informative data from hypothesis driven, well controlled experiments. These data will inform the design of ambitious, best-in-class, lead compositions. Our leads will be rigorously evaluated and honed until we are convinced our matured leads, called development candidates, can be prepared for testing in needy, and vulnerable patients.
Our products will be designed to speed the transition of cell therapy from hospital-based to outpatient treatments, increasing access to more patients at lower cost to patients, health systems, and insurers.
To achieve this mission, we are building diverse teams of talented, curious, and caring individuals who believe in our mission and our vision to be sustainable in our business plan, our work habits, and our personal lives.
Our values create: a foundation for mutual respect, an engaging harmony from many voices, and unselfish behavior to aid our colleagues.
This is ArsenalBio.
This is our Company.
This is our Company.
Salary : $113,600 - $139,100
