Scientist I, Immunohistochemistry (24218-U-670-IHC)

WHO WE ARE

Arsenal Biosciences Inc. is a clinical-stage programmable cell therapy company engineering advanced CAR T-cell therapies for solid tumors. We seek a talented and experienced Scientist I to work on-site based in our South San Francisco office. 

ArsenalBio’s mission and purpose are very clear: defeat cancer. With our programmable and computationally driven approach, our team is engineering medicines to attack cancer’s inherent multifaceted nature and overcome the challenges of addressing solid tumors with cell therapy.

Driven by a collective of diverse experts across multi-scientific disciplines and clinical and manufacturing expertise, we are united in our purpose to develop the optimal medicines for improving patients’ lives.

This means you’ll have the opportunity to work with the best talent in the field of cell therapy and be part of ONE TEAM, which advances therapies for patients who need it most.

Are you ready to revolutionize the field of cell-based immunotherapeutics and make a lasting impact on patient outcomes? ArsenalBio is seeking a highly motivated and innovative Scientist I - Immunohistochemistry to join our dynamic team.

As a key member of our research team, you will design and execute pioneering fluorescent and chromogenic multiplex and single-plex IHC and in-situ hybridization (ISH) assays. Your expertise will play a critical role in validating biomarkers and advancing translational research through the development of cutting-edge multiplex fluorescent tissue-based staining assays.

You will collaborate with cross-functional teams, manage external research partners, and mentor teammates to drive scientific excellence, all while presenting groundbreaking findings that push the boundaries of science.

• Independently design and execute cell- and tissue-based multiplex immunofluorescence and in-situ hybridization assays to drive the development of various cell-based immunotherapeutics 
• Perform cell- and tissue-based staining and image analysis to characterize target expression and on- and off-target binding in various organs and tissues, contributing to target validation, safety assessment, demographics, and tissue-based biomarker identification and validation for research and clinical use
• Summarize staining profiles of routine and novel biomarkers in human and animal model tissues and present findings to colleagues, including diverse management teams
• Execute and assist in developing standard operating procedures, including staining procedures, special stains, and exploratory assays to answer questions surrounding cutting-edge therapy
• Organize detailed methods, results, and data in an electronic lab notebook 
• Work collaboratively in matrix organizations via the contribution of data, ideas, and presentations
• Manage and communicate with CROs contracted to support validation and exploratory studies
• Assist in teaching and guiding research associates and scientists in histological and immunohistochemical techniques including grossing, processing, embedding, microtomy, staining, and experimental design 
• Assist in the maintenance of histology equipment including but not limited to microscopes, autostainers, and microtomes

• Bachelor's degree in Biology, Biochemistry, Cell Biology, and/or relevant histopathology-related degree with 7 years of relevant experience); OR Masters with 5 years relevant experience; OR PhD with 0-2 years relevant experience
• 5 years of experience in histology laboratory sciences preferred, including, but not limited to, human tissue and cell-based single and multiplex immunohistochemistry (IHC) , analysis, microtomy, and microscopy
• Robust experience and expertise in multiplex immunofluorescence assay (mIF) design, execution, scanning, and interpretation using digital pathology software
• Knowledge of basic histological features of normal tissues and cancer, with demonstrated ability to score intensity and percentage of staining
• Ability to adapt quickly, learn new skills, and think creatively to address evolving research priorities.
• Proven ability to collaborate, manage multiple projects to meet deadlines, and take on additional responsibilities as needed.
• Strong organizational skills, record-keeping and interpersonal communication skills (verbal and written) required

• Experience working in GLP, GCP, and CLIA-compliant environments and/or experience with GC/LP and CLIA regulatory standards for immunohistochemistry assay development
• Experience in companion and complementary diagnostics for clinical evaluation

BENEFITS AND PAY

ArsenalBio has a generous and comprehensive benefits package that includes but is not limited to medical, dental, and vision as well as mental health resources, virtual and telehealth options, coaching, infertility treatment, parental leave and health savings accounts. We also offer flexible work schedules and flexible time off, which includes two extra “Arsenal Days of Rest” every quarter for employees to recharge. 

Our people-first culture cultivates a deep respect for humanity, not only in those we serve but also in one another. We take pride in being part of a company that values and celebrates diversity—in experiences, ideas, and interests. We are empowered in an environment that embraces unity and inclusivity, fostering a sense of belonging and mutual respect.

We provide powerful tools to empower our employees to take charge of their career paths and reach their full potential. At ArsenalBio, we believe in investing in our employees' well-being—both professionally and personally—because our people are our most valuable asset. Our essential team members bring exceptional expertise in molecular biology, immunology, pharmacology, protein chemistry, computational biology, automation, genome engineering, software, and other fields to turn the possibilities of tomorrow into the realities of today.

We are committed to hiring the best talent from diverse backgrounds. A diverse workforce engenders richness of thought, creativity and discovery. We invite individuals who embrace intellectual achievement to bring their unique personal and professional journeys and together we will build transformative cell therapies for cancer patients.

We are an equal opportunity employer and deeply value diversity within our company. We do not discriminate based on race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability.

The estimated base salary for the preferred primary location of the San Francisco Bay area ranges from $110,200 - $135,000. Salary ranges for other locations may vary.  Base pay offered may vary based on job-related knowledge, experience, education, and location. Beyond these considerations, we are committed to pay equity and consider the internal equity of our current employees when making any final offers.

To all recruitment agencies: ArsenalBio does not accept agency resumes. Please do not forward resumes to our jobs alias or to ArsenalBio employees. ArsenalBio is not responsible for any fees related to unsolicited resumes.

Candidate Privacy Policy

Salary : $110,200 - $135,000