Isotope Laboratory Engineer

We are seeking a Technical Laboratory Engineer to manage the processing of Thorium-228 (Th) loading and Lead-212 (Pb) active substance ingredients, ensure compliance with safety and radioprotection protocols, and contribute to the development, handling, operation, and transfer of technology to external partners.

This laboratory-based role is fully on-site and requires strict adherence to safety and radiation protection guidelines.

• Execute, develop, and optimize the handling, processing and loading of Thorium-228 within a controlled laboratory environment.
• Operate within a glove box or hot cell to handle radioactive materials safely.
• Develop and strictly adhere to radioprotection and safety regulations in all procedures/protocols in handling Thorium-228 and daughters.
• Conduct quality control (QC) checks to ensure compliance with internal standards and maintain stable production.
• Oversee the generator's functioning in both preclinical and clinical settings.
• Analyze performance data (e.g., yield, purity, and stability) to identify areas for optimization or corrective actions.
• Work closely with engineers and scientists to enact process enhancements.
• Report findings to the relevant stakeholders.
• Oversee the qualification process for new and existing equipment, and ensure that all installations comply with Good Manufacturing Practices (GMP) and regulatory standards.
• Conduct operational and performance qualification (OQ/PQ) to validate proper functionality.
• Work with external manufacturing partners to resolve technical issues.
• Investigate root causes of failures and implement corrective actions.
• Ensure manufacturing partners adhere to quality and performance expectations.
• Develop and implement a maintenance schedule to prevent breakdowns.
• Work with maintenance teams and vendors to ensure long-term reliability.
• Maintain strict compliance with radioprotection guidelines, waste management, and decontamination procedures.
• Identify and mitigate risks associated with radioactive material handling.
• Participate in technology transfer to external partners.
• Document and refine standard operating procedures (SOPs) to improve efficiency and safety.
• Train internal team members and external partners on safe handling and processing protocols.
• Conduct periodic assessments to evaluate and enhance process efficiency and compliance.
• Collaborate with R&D and production teams to improve methodologies and workflows.

• BS/MS in Chemical Engineering, Nuclear Engineering, Radiochemistry, or a related field.
• Prior experience in radioactive material handling, laboratory operations, or nuclear medicine is highly preferred.
• Basic understanding of radioactivity and nuclear material safety.
• Hands-on experience with glove box operations.
• Strong knowledge of and strict adherence to safety protocols and radioprotection regulations.
• Ability to work with analytical and processing equipment in a controlled environment.
• Strong attention to detail and effective communication.

About Us

ARTBIO is a clinical-stage radiopharmaceutical company redefining cancer care by creating a new class of alpha radioligand therapies (ARTs). The unique ARTBIO approach selects the optimal alpha-precursor isotope (212Pb) and tumor-specific targets to create therapeutics with the potential for highest efficacy and safety. The company's AlphaDirect™ technology, a first-of-its-kind 212Pb isolation method, enables a distributed manufacturing approach for the reliable production and delivery of ARTs. ARTBIO is advancing multiple pipeline programs with lead program AB001 currently in first in human trials. ARTBIO is shaped by a long-standing scientific legacy with nearly a century of pioneering work in radiation therapy conducted at the University of Oslo and Norway’s Radium Hospital. For more information, visit www.artbio.com, and follow us on LinkedIn and Twitter. 

As an emerging, global biotech with locations in Boston, Massachusetts, Basel, Switzerland, London, England and Oslo, Norway, we take advantage of diverse scientific depth and insights which makes ARTBIO a unique place to work.  We are driven by a desire to do better for cancer patients, lowering the burden of toleration and safety while at the same time raising the bar on clinical efficacy and duration. 

EEO Statement

ARTBIO is proud to be an equal opportunity workplace and is an affirmative action employer. We are committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status. If you have a disability or special need that requires accommodation, please let us know.