What are the responsibilities and job description for the Associate Scientist, Process Development position at Artiva Biotherapeutics?
About Artiva:
Artiva is clinical-stage biotechnology company focused on developing natural killer (NK) cell-based therapies for patients suffering from devastating autoimmune diseases and cancers.
Artiva’s lead product candidate, AlloNK, is a non-genetically modified, off-the-shelf, allogeneic, cryopreserved NK cell therapy designed to enhance the antibody-dependent cellular cytotoxicity (ADCC) effect of mAbs to drive B-cell depletion and to be administered in the community setting. Unlike CAR-T and any genetically modified cell therapy, AlloNK is a non-genetically modified NK cell therapy candidate and has not shown any secondary malignancies in our clinical trials, which is a benefit in an autoimmunity setting. Using the company’s proprietary cell therapy manufacturing platform, Artiva can generate thousands of doses of cryopreserved, infusion-ready AlloNK cells from a single cord blood unit. The FDA has granted Fast Track designation to AlloNK in combination with rituximab or obinutuzumab for the treatment of class III or IV lupus nephritis, and AlloNK in combination with rituximab for the treatment of relapsed or refractory non-Hodgkin lymphoma of B-cell origin (B-NHL).
AlloNK, is currently being evaluated in combination with B-cell targeted mAbs in
patients with autoimmune diseases and cancers, such as lupus nephritis, SLE, rheumatoid arthritis, pemphigus vulgaris, the ANCA-associated vasculitis subtypes GPA/MPA, and B-NHL. In addition, we are also pursuing AlloNK and our CAR-NK product candidates in multiple indications through collaborator-funded trials. Artiva’s cell therapy manufacturing platform incorporates cell expansion and activation technology developed by Artiva’s strategic partner, GC Cell Corporation, a member of the GC family of companies, a leading healthcare company in Korea.
Artiva is headquartered in San Diego and backed by leading venture investors including 5AM Ventures, RA Capital Management and venBio Partners.
For more information, visit www.artivabio.com.
Job Summary:
The Associate Scientist, Process Development Analytics will be responsible for completing analytical testing in support of the development of off-the-shelf, allogeneic, natural killer (NK) cell-based therapies. Operating in a cross-functional and dynamic environment, the individual will work closely with the Analytical Development team to transfer and conduct in-vitro testing for Process Development activities. The ideal candidate should have a proven track record of conducting analytical testing for cell therapy products.
Duties/Responsibilities:
- Conduct routine in-vitro testing to support Process Development experiments and enhance process understanding.
- Analyze data, interpret results, trend data and maintain detailed records.
- Provide data for technical reports, standard operating procedures, and regulatory submissions in support of process development activities
- Manage assay transfer from internal Artiva functional groups to Process Development as needed.
- Identify potential problems, investigate, troubleshoot assays, and work to resolve any issues.
- Coordinate activities within a collaborative work environment across functional teams to support process development as well as the characterization of Artiva’s products.
- Train Process Development personnel on analytical testing procedures as needed.
Requirements:
- B.S. with 8 years or M.S in a biological field with a minimum of 5 years of relevant laboratory experience.
- Hands-on experience (equipment and software) with flow cytometry, plate readers, and automated cell counters required.
- Experience with functional assays, IncuCyte a plus
- Strong organizational, recording keeping, time management, and communication skills are required.
- Previous exposure to analytical testing in a Pharma/Biotech, regulated (GxP) environment is preferred.
- Experience in cell therapy, immunology, or oncology is strongly preferred.
Why you should apply:
We have a fantastic team and philosophy! We are passionate – we deeply care about our team, our science, and improving the lives of patients. We are tenacious – laser-focused on our mission and undeterred in our commitment to deliver life-saving medicines for cancer patients. We are innovative - pushing into new frontiers for patient benefit. We are transparent - believers in flat, accessible, and open communication paths. We are inclusive – committed to the diversity of our team and ensuring that all voices are heard.
In addition to a great culture, we offer:
· A beautiful facility
· An entrepreneurial, highly collaborative, and innovative environment
· Comprehensive benefits, including:
- Medical, Dental, and Vision
- Group Life Insurance
- Long Term Disability (LTD)
- 401(k) Retirement Plan
- Employee Assistance Program (EAP)
- Flexible Spending Account (FSA)
- Paid Time Off (PTO)
- Company paid holidays, including the year-end holiday week
- Our recognition program, Bonus.ly, is where you can trade in points earned for things you want.
If all this speaks to you, come join us on our journey!
Base Salary: $103,000 - $125,000. Exact compensation may vary based on skills and experience.
Salary : $103,000 - $125,000
