Demo

Principal Scientist, Protein Engineering

Astellas
San Francisco, CA Full Time
POSTED ON 2/11/2025
AVAILABLE BEFORE 5/11/2025

Would you like to join an international team working to improve the future of healthcare? Do you want to enhance the lives of millions of people? Grifols is a global healthcare company that since 1909 has been working to improve the health and well-being of people around the world. We are leaders in plasma-derived medicines and transfusion medicine and develop, produce and market innovative medicines, solutions and services in more than 110 countries and regions.

GigaGen, a subsidiary of Grifols, discovers and develops next-generation recombinant antibody therapeutics. Our core technology utilizes a microfluidic droplet system to capture and immortalize diverse immune repertoires, which can then be mined for exceptional monoclonals or enriched and used as high-potency polyclonal therapeutics. Our preclinical pipeline includes several recombinant polyclonal products for infectious diseases and a monoclonal antibody with a unique mechanism for oncology, which is entering the clinic.

We are seeking an innovative and motivated Senior Scientist II to develop and implement novel capabilities and assays (in particular those related to virology targets) to functionally characterize our therapeutic antibody drug candidates, and to help spearhead projects to continually improve and expand upon our internal capabilities.

Primary Responsibilities :

  • Developing antigen expression systems to create target-expressing cell lines and pseudoviruses.
  • Designing and performing in vitro viral infection functional assays.
  • Analyzing data and discussing results at internal and external meetings.
  • Brainstorming and troubleshooting research projects with other scientists.
  • Researching the literature to devise novel application ideas.
  • Writing protocols for new capabilities and training other technical staff.
  • Assisting in data generation, curation, and writing for publications.
  • Mentoring other staff in proper lab skills, experiment design, and data analysis.
  • Identifying and evaluating external vendors.

Additional Responsibilities, Skills & Requirements :

  • Bachelor with 10 years of experience or Masters with 8 years of experience or PhD with 5 years of experience.
  • Understanding of pre-clinical and clinical aspects of viral infection and "at the bench skills" to translate those concepts into laboratory techniques.
  • Experience with developing functional in vitro viral neutralization assays including pseudovirus engineering and target cell line development.
  • Strong technical foundation in molecular virology and cell biology.
  • Record of scientific achievement and proficiency in advanced biochemical, cellular, and / or molecular techniques.
  • Skills in one or more of the following areas is required : mammalian cell culture, molecular biology, protein engineering, high-throughput systems.
  • Strong scientific understanding and logical thinking.
  • Technical writing skills and experience authoring manuscripts.
  • Comfort in designing experiments from scratch and thinking creatively.
  • Ability to work independently and prioritize work across multiple projects.
  • Experience leading a team and managing direct reports.
  • This job description is intended to present the general content and requirements for the performance of this job. The description is not to be construed as an exhaustive statement of duties, responsibilities, or requirements. Managers and supervisors may assign other duties as needed.

    J-18808-Ljbffr

    If your compensation planning software is too rigid to deploy winning incentive strategies, it’s time to find an adaptable solution. Compensation Planning
    Enhance your organization's compensation strategy with salary data sets that HR and team managers can use to pay your staff right. Surveys & Data Sets

    What is the career path for a Principal Scientist, Protein Engineering?

    Sign up to receive alerts about other jobs on the Principal Scientist, Protein Engineering career path by checking the boxes next to the positions that interest you.
    Income Estimation: 
    $125,958 - $157,570
    Income Estimation: 
    $120,989 - $162,093
    Income Estimation: 
    $74,806 - $91,633
    Income Estimation: 
    $71,928 - $87,026
    Income Estimation: 
    $145,337 - $174,569
    Income Estimation: 
    $125,958 - $157,570
    Income Estimation: 
    $120,989 - $162,093
    Income Estimation: 
    $74,806 - $91,633
    Income Estimation: 
    $71,928 - $87,026
    Income Estimation: 
    $145,337 - $174,569
    Income Estimation: 
    $145,337 - $174,569
    Income Estimation: 
    $153,127 - $203,425
    Income Estimation: 
    $139,626 - $193,276
    Income Estimation: 
    $164,650 - $211,440
    Income Estimation: 
    $130,030 - $173,363
    Income Estimation: 
    $130,030 - $173,363
    Income Estimation: 
    $194,895 - $259,743
    Income Estimation: 
    $192,057 - $260,440
    Income Estimation: 
    $249,515 - $311,938
    Income Estimation: 
    $155,477 - $213,492
    Income Estimation: 
    $155,477 - $213,492
    Income Estimation: 
    $161,172 - $205,272
    Income Estimation: 
    $120,254 - $158,147
    Income Estimation: 
    $225,010 - $318,974
    Income Estimation: 
    $208,337 - $274,406
    View Core, Job Family, and Industry Job Skills and Competency Data for more than 15,000 Job Titles Skills Library

    Job openings at Astellas

    Astellas
    Hired Organization Address Burlington, VT Full Time
    Developing innovative therapies is one of the most challenging, most essential, and personally rewarding fields in scien...
    Astellas
    Hired Organization Address Hartford, CT Full Time
    Developing innovative therapies is one of the most challenging, most essential, and personally rewarding fields in scien...
    Astellas
    Hired Organization Address Asheville, NC Full Time
    Developing innovative therapies is one of the most challenging, most essential, and personally rewarding fields in scien...
    Astellas
    Hired Organization Address Raleigh, NC Full Time
    Do you want to be part of an inclusive team that works to develop innovative therapies for patients? Every day, we are d...

    Not the job you're looking for? Here are some other Principal Scientist, Protein Engineering jobs in the San Francisco, CA area that may be a better fit.

    Principal Scientist, Protein Engineering

    Astellas Pharma, South San Francisco, CA

    Principal Scientist, Protein Engineering

    Astellas, South San Francisco, CA

    AI Assistant is available now!

    Feel free to start your new journey!