What are the responsibilities and job description for the Senior Scientist USP position at Astrix?
Biopharmaceutical contract manufacturing company specializing in the production of therapeutic proteins and antibodies manufactures drugs for its clients clinical trials.
Upstream Process Development Sr. Scientist
- Responsible for cell line development, cell culture technologies, and bioprocess development and optimization activities in R&D.
- Development of cell culture platforms such as media and bioprocess technologies for batch, fed-batch, and perfusion systems from early phase development (i.e., shake flasks and small scale high throughput bench top bioreactors) to the pilot scale to support cGMP-Like tox material production.
- Leads multiple projects to meet timeline, budget and scope commitments and has good working knowledge of cell culture development pertaining to drug development.
- Proficient working knowledge of all relevant disciplines pertaining to the drug development process and knowledge of relevant business elements.
- Supervise and mentor other colleagues by providing guidance, coaching, and career development support.
- Independently optimize and develop robust and scalable bioprocess platforms primarily fed-batch and perfusion systems.
- Drive innovation by scouting, assessing, developing, and implementing new technology platforms such as but not limited to PAT, process control, culture media and feed media optimization, etc.
- Support additional R&D Services teams (e.g., Cell line development, downstream development, microbial USP and Analytical Development) by generating, reviewing, and interpreting USP results.
Essential Experience and Requirements
- Ph.D. in Bioprocess or Biochemical Engineering with at least 7 years of relevant experience (including >3 years at USP industrial experience), or M.Sc. with, at least 10 years of relevant experience (including >2 years at USP industrial experience).
- Must have a proven track record and expertise in high throughput process characterization and optimization techniques and tools (i.e. DoE, statistical analysis, QbD).
- Must have a proven track record of developing, optimizing and scale up of Continuous Perfusion and Fed-batch systems.
- Must have a proven track record and expertise in upstream process scale-up and scale-down to support commercialization.
This job description is a complete list of all desired skills but not all are required. We strongly encourage candidates who have some of the skills to apply. We look forward to a conversation to learn more about you!
Salary : $85,000 - $130,000
