Scientist, Molecular and Cell Biology

Profoundly Improve People’s lives by Revolutionizing the Delivery of RNA Therapeutics

At Avidity Biosciences, we are passionate about the impact of every employee in realizing our vision of improving people’s lives by delivering a new class of RNA therapeutics. Avidity is revolutionizing the field of RNA with its proprietary AOCs, which are designed to combine the specificity of monoclonal antibodies with the precision of oligonucleotide therapies to address targets and diseases previously unreachable with existing RNA therapies. If you are a committed, solution-oriented thinker, join us in making a difference and become part of our growing culture that is integrated, collaborative, agile and focused on the needs of patients. 

Avidity Biosciences, Inc.'s mission is to profoundly improve people's lives by delivering a new class of RNA therapeutics - Antibody Oligonucleotide Conjugates (AOCs™). Utilizing its proprietary AOC platform, Avidity demonstrated the first-ever successful targeted delivery of RNA into muscle and is leading the field with clinical development programs for three rare muscle diseases: myotonic dystrophy type 1 (DM1), Duchenne muscular dystrophy (DMD) and facioscapulohumeral muscular dystrophy (FSHD). Avidity is broadening the reach of AOCs with its advancing and expanding pipeline, including programs in cardiology and immunology through internal discovery efforts and key partnerships. Avidity is headquartered in San Diego, CA. For more information about our AOC platform, clinical development pipeline, and people, please visit www.aviditybiosciences.com and engage with us on LinkedIn and X.

The Opportunity

As Avidity transitions from late stage clinical to commercial operations, an effective quality control strategy will be critical to ensuring the safety, efficacy and reproducibility of our drug products.  To facilitate these efforts, we are seeking a Scientist to join the Analytics group with experience in developing and optimizing robust cell-based assays for later phase clinical programs. The position will also support preclinical development of second-generation AOC therapeutics. This is a unique opportunity and will enable the individual to interact with multiple departments including Chemistry, Biology, and Bioanalytical Sciences. This individual will work in a high-paced matrix environment and must be able to communicate and collaborate between them effectively. 

What You Will Contribute

●        Creative and independent assay design skills

●        A solid and independent understanding of molecular biology workflows to design and create fluorescence- and luminescent-based cell reporter assays.

●        Experience with molecular pharmacology principles used to characterize ligand receptor interactions

●        Wet-bench efforts towards analytical assay execution and validation

●        Method and SOP development, optimization (including DOE), and documentation

●        CRO management to support early and late phase GMP release testing.

●        Hands on experience with cell line development and engineering (viral and/or CRISPR)

●        An understanding of FDA regulations related to GMP analytical testing including USP and ICH guidance

●        A positive can-do attitude that thrives working as a part of a highly efficient team

What We Seek

●        A PhD in biology, pharmaceutical sciences, bioengineering, or equivalent

●        1 -2 years of pharmaceutical experience or 3 -5 postdoctoral and industry experience

●        Experience with cell and molecular pharmacology and assay development.

●        Proven ability to thrive and enable success in a cross-functional and collaborative environment.

●        Excellent communication and interpersonal skills and the ability to facilitate constructive and expedient problem-solving.

●        Ability to multi-task, manage conflict, and work in a fast-paced environment.

●        R or python-based data wrangling skills to facilitate data analysis workflows (preferred but not required)

What We Will Provide To You

●        The base salary range for this role is $138,250 - $141,750.The final compensation will be commensurate with such factors as relevant experience, skillset, internal equity and market factors.

●        Avidity offers competitive compensation and benefits, which include the opportunity for annual and spot bonuses, stock options, and RSUs, as well as a 401(k) with an employer match. In addition, the comprehensive wellness program includes coverage for medical, dental, vision, and LTD, and four weeks of time off.

●        A commitment to learning and development which includes a variety of programming internally developed by and for Avidity employees, opportunities for job-specific training offered by industry, and an education reimbursement program.