Scientist III/ IV, Exploratory Biomarkers

We are seeking a driven, energetic, results-oriented Scientist III or IV to join the Biomarker Discovery group of the Immunology and Respiratory Research Therapeutic Area in Ridgefield CT. This individual will develop in vitro TE/PD and disease biomarker assays to support the Immunology and Respiratory Department portfolio projects and use innovative technologies to discover biomarkers to advance our novel research programs. This position requires hands-on experience on TE/PD and disease biomarker assay development in drug discovery, primary animal/human cell culture systems, ligand-binding assays, attentional to experimental detail, teamwork as well as strong communication and organizational skills. Flow cytometry experience is preferred.

Duties & Responsibilities

• As a technology expert, develops and implement experimental approaches that contribute to the Biomarker Discovery group goals in an independent and efficient manner, with minimal supervision
• Designs, executes and troubleshoots routine and innovative TE/PD (including direct and indirect TE) and disease biomarker assays using animal/human matrices, analyzes experimental data, interprets outcome of experiments and proposes appropriate follow-up experimental plans
• Interacts regularly with colleagues in the Biomarker group and other organization functions to move new therapeutic concepts through their lifecycle
• Keeps abreast with literature and extracts relevant information from published protocols
• Present own work at internal and external meetings
• Proposes and contributes to the incorporation of new technologies and/or assume departmental responsibility for technical aspects of portfolio projects
• Trains junior scientists in all areas of laboratory operations, productively contributes in a matrix organization and shares ideas across the department
• Co-authors peer-reviewed manuscripts
• Adapts best strategies internally and externally, complies with applicable regulations, performing all work in a safe manner and maintains proper records in accordance with SOPs and policies

Requirements

• Strong hands-on experience with development of TE/PD and disease biomarker assays in Drug Development, including direct and indirect TE assays and receptor/target occupancy assays
• Experience with immunoassays
• Experience using a variety of standard laboratory techniques such as mammalian cell tissue culture, various ligand-binding assay formats (i.e ELISA), peripheral blood cell cell isolation and culture, DNA/RNA extraction, RT-qPCR, western blot.
• Ability to learn new technology and concepts
• Proficiency in Microsoft Office, experience with Flow cytometry data analysis tools (i.e FlowJo) and GraphPrism softwares
• Good verbal and written communication skills.
• Independent thinker, planner, and executor of technical activities.
Strong analytical skills to effectively present test data and other related findings.

Scientist III:

Master´s Degree with 3 years experience in related scientific discipline or Bachelor´s Degree with 7 years experience in related scientific discipline or equivalent experience in related field

Scientist IV:

Compensation:

Desired Skills, Experience and Abilities

• Hands-on experience with flow cytometry
• Experience with method validation in Drug Discovery
• Experience with omics technologies (i.e. proteomics), in particular application to biomarker discovery
Experience with handling of various clinical specimens

Eligibility Requirements:

• Must be legally authorized to work in the United States without restriction.
• Must be willing to take a drug test and post-offer physical (if required).
• Must be 18 years of age or older.