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Chemical Biology Research Scientist

BioPharma Consulting JAD Group
Boston, MA Contractor
POSTED ON 4/1/2025
AVAILABLE BEFORE 5/31/2025

We are seeking a Chemical Biology Research Scientist. Our mission is to develop treatments for serious diseases, including those with traditionally difficult-to-drug targets. In this lab-based role, the scientist will apply novel covalent drug discovery techniques to identify and validate ligands for challenging proteins. The ideal candidate is a motivated, detail-oriented, and lifelong learner with expertise in covalent drug discovery and compound screening.

Key Responsibilities:

  • Conduct high-throughput compound screening.
  • Design, execute, and troubleshoot novel screening approaches for covalent ligand discovery.
  • Proactively communicate verbally and in writing to engage effectively with multidisciplinary team members.
  • Collaborate with team members to coordinate screening stages and timelines.

Knowledge and Skills:

  • Expertise in covalent chemoproteomics and data analysis.
  • Strong understanding of compound binding affinity, selectivity, reactivity, and kinetics.
  • Experience with automation for liquid handling.
  • Proficiency in affinity capture methods, including immunoprecipitation.
  • Experience with Western blot analysis.
  • Strong background in cell biology, including cell culture and lentiviral-based expression.

Education and Experience:

  • Ph.D. in Chemistry, Biochemistry, Chemical Biology, or a related field; or
  • Master's degree with at least 3 years of relevant experience.
  • Hands-on experience in covalent drug discovery, compound screening, and biochemical assays.
  • Strong track record of scientific research and problem-solving in a laboratory setting.

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