Bioconjugation Co-Op

Company Overview

Dyne Therapeutics is focused on discovering and advancing innovative life-transforming therapeutics for people living with genetically driven neuromuscular diseases. Leveraging the modularity of its FORCE™ platform, Dyne is developing targeted therapeutics that deliver to muscle and the central nervous system (CNS). Dyne has a broad pipeline for neuromuscular diseases, including clinical programs for myotonic dystrophy type 1 (DM1) and Duchenne muscular dystrophy (DMD) and preclinical programs for facioscapulohumeral muscular dystrophy (FSHD) and Pompe disease.

Role Summary

The bioconjugation co-op supports the bioconjugation of oligonucleotides and proteins for FORCE platform development to advance Dyne research. This role is wet-lab based and involves collaborations to work closely with scientists in cross-functional drug discovery teams. This person will participate and learn the bioconjugation process of antibody-oligonucleotide conjugates and the related biochemical assays for drug discovery and development projects. The student is expected to be highly motivated and passionate about antibody-oligonucleotide drug discovery and adopt to fast pace dynamic environment.

This role is based in Waltham, MA without the possibility of being remote. This is a 6-month position beginning in July.  

Primary Responsibilities Include

• Conduct and support biochemical assays for conjugates in bioconjugation processes, such as mass spectrometry, HPLC, SDS-PAGE, ELISA, BCA, and UV-vis, etc.
• Learn about the bioconjugation and purification of oligonucleotide-protein conjugates and gain hand-on experience on multi-step conjugation process
• Learn the process of early drug discovery with the FORCE platform through collaboration with Platform Development or cross-functional teams and support the innovations of FORCE platforms
• Analyze, report, and present experimental data to the Platform Development team (or collaborator teams if needed) under supervision
• Support lab maintenance and document technical reports on electronic lab notebook (ELN)
  
  
  

Education And Skills Requirements

• Actively pursuing a bachelor’s or master’s degree in chemistry, biochemistry, or related disciplines
• Basic understanding of biochemical assays such as ELISA, UV-vis, gel electrophoresis, liquid chromatography
• Prior hands-on experience in wet chemistry and basic understanding of oligo and/or protein science
• Strong knowledge on Microsoft Office including Excel, PowerPoint, and Word
• Experience on analytical chemistry is highly preferred
• Experience on data analysis software applications, such as Origin and GraphPad Prism, is preferred
• Excellent oral and written skills as well as time management skills
  
  
  

The statements contained herein reflect general details as necessary to describe the principles functions for this job, the level of knowledge and skill typically required, and the scope of responsibility, but should not be considered an all-inclusive listing of work requirements. Individuals may perform other duties as assigned, including work in other functional areas to cover absences or relief, to equalize peak work periods or otherwise balance workload.

This description is not intended to be constructed as an exhaustive list of duties, responsibilities, or requirements for the position. This position may change or assume additional duties at any time. The employee may be requested to perform different or additional duties as assigned. All Employees are expected to adhere to all company policies and act as a role model for company values.

Dyne Therapeutics is an equal opportunity employer and will not discriminate against any employee or applicant on the basis of age, color, disability, gender, national origin, race, religion, sexual orientation, veteran status, or any classification protected by federal, state, or local law.