Senior Research Associate, Platform Development

Company Overview

Dyne Therapeutics is discovering and advancing innovative life-transforming therapeutics for people living with genetically driven neuromuscular diseases. Leveraging the modularity of its FORCE™ platform, Dyne is developing targeted therapeutics that deliver to muscle and the central nervous system (CNS). Dyne has a broad pipeline for neuromuscular diseases, including clinical programs for myotonic dystrophy type 1 (DM1) and Duchenne muscular dystrophy (DMD) and preclinical programs for facioscapulohumeral muscular dystrophy (FSHD) and Pompe disease.

Role Summary

Dyne is seeking a talented and highly motivated Senior Research Associate with a background in biology, chemistry, or biochemistry to help our Bioconjugation team advance therapeutics research and support drug discovery programs. This team member will collaborate closely with in vitro/in vivo biology colleagues to generate and characterize research materials and will also help establish and contribute to the operations of our laboratories.

The ideal candidate is a highly motivated individual with exceptional communication and collaboration skills. The qualified candidate will have the opportunity to build, contribute to, and expand our innovative platform technology and advance Dyne's mission of pioneering life-transforming therapies for patients with serious muscle diseases.

This role is based in Waltham, MA without the possibility of being fully remote.

Primary Responsibilities Include

• Generate research therapeutic candidates for in vitro and in vivo studies
• Design, optimize and execute protein bioconjugation reactionswith multiple proteins and payloads ranging from milligram to gram scale
• Utilize AKTA systems to perform purifications on raw materials and conjugates using a variety of chromatography techniques (IEX, HIC, CHT, etc.)
• Perform Tangential Flow Filtration (TFF; UF/DF) from milliliter to multi-Liter scale
• Write technical reports to support technical transfers
• Analyze the stability of therapeutic materials
• Perform biochemical analysis on in-process and final purified conjugates- including, but not limited to, the following techniques: Mass Spectrometry (LC-MS), SDS-PAGE, BCA, HPLC/UPLC, and UV-vis.
• Identify and validate novel therapeutic targets to expand our FORCE platform
• Communicate experimental results to a diverse audience of scientific collaborators
• Help maintain a high-functioning laboratory environment
• Contribute to critical discussions of therapeutic structure, activity, and function
• Contribute to building a positive, team-oriented culture
  
  
  

Education And Skills Requirements

• A master’s degree in biology, chemistry, or biochemistry with 3 years of hands-on industry experience, or a BS with 5 years of experience in early drug discovery and development, is required
• Skills with chromatographic separation are essential (e.g. SEC, HIC, IEX)
• Skills with protein assays are also essential (e.g. ELISA, BCA, SDS-PAGE)
• Skills with analytical methods are a plus (e.g. HPLC, UPLC, LC-MS)
• Experience with protein bioconjugation, antibody-drug conjugates (ADCs) or antibody-oligonucleotide conjugates is a plus
• Strong organizational skills and attention to detail
• Ability to effectively communicate ideas and document research
• Experienced in software applications (Prism, Excel, PowerPoint)
  
  
  

The statements contained herein reflect general details as necessary to describe the principles functions for this job, the level of knowledge and skill typically required, and the scope of responsibility, but should not be considered an all-inclusive listing of work requirements. Individuals may perform other duties as assigned, including work in other functional areas to cover absences or relief, to equalize peak work periods or otherwise balance workload.

This description is not intended to be constructed as an exhaustive list of duties, responsibilities, or requirements for the position. This position may change or assume additional duties at any time. The employee may be requested to perform different or additional duties as assigned. All Employees are expected to adhere to all company policies and act as a role model for company values.

Dyne Therapeutics is an equal opportunity employer and will not discriminate against any employee or applicant on the basis of age, color, disability, gender, national origin, race, religion, sexual orientation, veteran status, or any classification protected by federal, state, or local law.