Senior Scientist II, Biologics Analytical Development

Company Description

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas immunology, oncology, neuroscience, and eye care and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us atwww.abbvie.com. Follow @abbvie onX,Facebook,Instagram,YouTube,LinkedInandTik Tok.

Job Description

AbbVies Biologics CMC Analytical Research and Development Group in South San Francisco has an exciting opportunity for a Senior Scientist II to join a dynamic team of scientists responsible for all aspects of CMC analytical development required to move biologic candidates from discovery into and through clinical studies.

In this lab-based role, you will utilize your knowledge of protein chemistry and expertise in chromatography (LC) and capillary electrophoresis (CE) to contribute to development of AbbVies growing pipeline of clinical stage biotherapeutics, which include novel bispecific constructs, antibody-drug conjugates, and monoclonal antibodies. You will characterize and investigate attributes of biologic drug candidates to provide product and process understanding, as well as develop innovative analytical methods that provide deeper insights into protein biotherapeutics across the development spectrum from candidate liability screening to process development to clinical development.

Key Responsibilities Include

• Independently develop state of the art capillary electrophoresis and HPLC methods to characterize biotherapeutic proteins and their associated variants and impurities.
• Characterize post-translational modifications and structure-activity relationships of products under development.
• Develop innovative approaches to solve difficult analytical challenges.
• Represent the Biologics CMC Analytical Research and Development Group as a subject matter expert on cross functional project teams.
• Develop, qualify/validate, and transfer fit-for-purpose QC release and stability methods.
• Provide technical support and oversight for QC testing occurring at internal and external GMP laboratories.
• Plan and author characterization, comparability, and quality sections of regulatory submissions (INDs/CTDs).
• Engage and influence the broader scientific community through publications and poster and oral presentations at industry conferences.
  
  
  

Qualifications

• Bachelors Degree or equivalent education and 12 years of experience, Masters Degree or equivalent education and 10 years of experience, PhD and 4 years of experience.
• Must possess a solid understanding of protein chemistry and biochemistry, particularly as it relates to biotherapeutic protein drug development.
• Demonstrated proficiency in developing and performing capillary electrophoresis and HPLC methods as they apply to protein characterization.
• Experience with CMC analytical development of monoclonal antibodies or related biotherapeutic proteins is preferred, but not required.
• Proven record of advanced technical/scientific achievement and innovation.
• Quality control and/or GMP experience is beneficial.
• Must have strong written and verbal communications skills.
• Must be capable of working in a fast-paced, collaborative environment and managing multiple concurrent projects with a high degree of independence.
  
  
  

Additional Information

Applicable only to applicants applying to a position in any location with pay disclosure requirements under state orlocal law:

• On-site position located at AbbVie's ABA site in South San Francisco, CA.
• The compensation range described below is the range of possible base pay compensation that the Companybelieves ingood faith it will pay for this role at the timeof this posting based on the job grade for this position.Individualcompensation paid within this range will depend on many factors including geographic location, andwemay ultimatelypay more or less than the posted range. This range may be modified in thefuture.
• We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick),medical/dental/visioninsurance and 401(k) to eligibleemployees.
• This job is eligible to participate in our short-term incentiveprograms.
• This job is eligible to participate in our long-term incentiveprograms
  
  
  

Note: No amount of payis considered to bewages or compensation until such amount is earned, vested, anddeterminable.The amount and availability of any bonus,commission, incentive, benefits, or any other form ofcompensation and benefitsthat are allocable to a particular employee remains in the Company's sole andabsolutediscretion unless and until paid andmay be modified at the Companys sole and absolute discretion, consistent withapplicable law.

AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives, serving our community and embracing diversity and inclusion. It is AbbVies policy to employ qualified persons of the greatest ability without discrimination against any employee or applicant for employment because of race, color, religion, national origin, age, sex (including pregnancy), physical or mental disability, medical condition, genetic information, gender identity or expression, sexual orientation, marital status, status as a protected veteran, or any other legally protected group status.

US & Puerto Rico only - to learn more, visithttps://www.abbvie.com/join-us/equal-employment-opportunity-employer.html

US & Puerto Rico applicants seeking a reasonable accommodation, click here to learn more:

https://www.abbvie.com/join-us/reasonable-accommodations.html