Senior Scientist, Medicinal Chemistry

How will your role help us transform hope into reality?

Blueprint Medicines is seeking a motivated scientist with a B.S., M.S. or PhD to engage in medicinal chemistry programs that lead to the identification of drug candidates for clinical development.  You will need to possess strong core competence in modern synthetic organic synthesis and medicinal chemistry to be successful in this opportunity.

What will you do?

• Design, plan, and execute multi-step organic syntheses and purifications of small molecules as a member of cross-functional research teams


• Work with internal/external teams to efficiently design and deliver high quality compounds for biological evaluation


• Summarize and interpret analytical data and generate research reports/presentations for both internal and external use


• Work collaboratively across diverse functions within and across multidisciplinary project teams


• Work with the chemistry project leader to effectively manage the internal/external chemistry team


• Anticipate and ensure the development of high-quality synthetic routes to key intermediates and compounds


• Work with the chemistry project leader to identify critical issues and devise medicinal chemistry strategies to advance high quality chemical matter


• Effectively communicate new project proposals, medicinal chemistry strategies, innovative ideas and results, both informally and in meetings with colleagues and management

What minimum qualifications do we require?

• B.S. in organic chemistry or a related field and 12 years of medicinal chemistry experience in a pharmaceutical/ biotechnology setting OR


• M.S. in organic chemistry or a related field and 9 years of medicinal chemistry experience in a pharmaceutical/ biotechnology setting OR


• PhD in organic chemistry or a related field and 3 years of medicinal chemistry experience in a pharmaceutical/ biotechnology setting

What additional qualifications will make you a stronger candidate?

• Demonstrated experience in the design and synthesis of bioactive compounds, with experience in the design and preparation of heterobifunctional and monovalent degraders preferred


• Demonstrated exemplary skills in all aspects of modern organic and medicinal chemistry, including data analysis, single compound synthesis, small parallel library design and synthesis, structure-based design and analytical and purification methods


• Experience implementing medicinal chemistry strategies across all stages of medicinal chemistry from hit identification, through to lead optimization to achieve program goals


• Experience functioning within strong multi-disciplinary teams and utilizing cross-functional information, such as biochemical activity, ADME and pharmacological data, to drive medicinal chemistry strategies


• Demonstrated experience in complex problem solving through in-depth analysis of data


• At home in a results-driven, highly accountable environment where you can make a clear impact


• A team player, who listens effectively and invites response and discussion


• A collaborator who communicates in an open, clear, complete, timely and consistent manner


• Commitment to our Core Values: Patients First, Thoughtfulness, Urgency, Trust, Optimism

Why Blueprint?

At Blueprint Medicines, we achieve impactful results because of our global crew of compassionate innovators – the Blue Crew. Through authentic relationships and our collective entrepreneurial spirit and action, we are each empowered to take ownership and execute with strategic prioritization. We put trust in our people to break through norms and conventions using their individual strengths and insights, which drives our success.

This is the place where the extraordinary becomes reality, and you could be part of it.

Patients are waiting. Are you ready to make the leap?

Equity, Diversity, Inclusion and Affirmative Action

At Blueprint Medicines, we foster a culture of equity, diversity and inclusion.  A proud Equal Employment Opportunity and Affirmative Action employer, we consider all qualified applicants without regard to race, color, sex, gender identity or expression, sexual orientation, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, or any other characteristic protected under applicable law.  We are also an E-Verify Employer.  We will make reasonable accommodations, absent undue hardship, for qualified individuals with known disabilities. If you are an individual with a disability in need of an accommodation with the application or recruiting process, please reach out to TotalRewards@blueprintmedicines.com. 

For more information, please see our EEO-AA Policy Statement, the E-Verify Participation Poster, the Right to Work Poster, and/or the EEO Know Your Rights Poster, as well as our Pay Transparency Statement. 

Blueprint Medicines is a global, fully integrated biopharmaceutical company that invents life-changing medicines. We seek to alleviate human suffering by solving important medical problems in two core focus areas: allergy/inflammation and oncology/hematology. Our approach begins by targeting the root causes of disease, using deep scientific knowledge in our core focus areas and drug discovery expertise across multiple therapeutic modalities. We have a proven track record of success with two approved medicines, including bringing our medicine to patients with systemic mastocytosis (SM) in the U.S. and Europe. Leveraging our established research, development, and commercial capability and infrastructure, we now aim to significantly scale our impact by advancing a broad pipeline of programs ranging from early science to advanced clinical trials in mast cell diseases including SM and chronic urticaria, breast cancer and other solid tumors.