What are the responsibilities and job description for the Director/Senior Director, Antibody Development & Engineering San Francisco, CA/Hybrid position at BridgeBio Pharma?

Eidos Therapeutics, an affiliate of BridgeBio Pharma, is a Phase 3 developmental-stage biopharmaceutical company focused on addressing the large and growing unmet need in diseases caused by transthyretin, or TTR, amyloidosis, or ATTR. We seek to treat this well-defined family of diseases at their collective source by stabilizing TTR. Our investigational product, acoramidis (AG10), is an orally administered small molecule designed to potently stabilize TTR, a potentially best-in-class treatment aiming to halt the progression of ATTR diseases.

BridgeBio is a biopharmaceutical company founded to discover, create, test, and deliver transformative medicines to treat patients who suffer from genetic diseases and cancers with clear genetic drivers. We bridge the gap between remarkable advancements in genetic science in academic institutions and the delivery of meaningful medicines to patients. Founded in 2015, the company has built a portfolio of 30 drug development programs ranging from preclinical to late-stage development in multiple therapeutic areas including genetic dermatology, precision oncology, cardiology, endocrinology, neurology, pulmonology, and renal disease, with two approved drugs.

We are looking for a highly motivated and innovative scientist to join our biologics discovery group at BridgeBio. The selected candidate will work within a fast-paced, interactive, and innovative research team to lead discovery campaigns for novel antibodies. This role will lead the development of immunological functional assays and cross-functionally oversee future regulatory submissions.

Responsibilities

Design, develop and lead multiple antibody discovery campaign efforts with CROs, including biochemical and functional assay screening
Lead antibody engineering efforts for affinity maturation campaigns, developability, and immunological enhancement
Lead the development of preclinical animal models with CROs to assess lead candidates
Engage in scientific discussion with collaborators and management to evaluate ongoing projects
Develop and optimize the SOPs, validation protocols, provide technical assistance and train research associates
Oversee wet lab activities including tissue culture, PBMC isolation, protein expression and purification, functional assays, and flow cytometry
Maintain strong understanding of state-of-the-art protein engineering

No matter your role at BridgeBio, successful team members are :

Patient Champions, who put patients first and uphold strict ethical standards

Entrepreneurial Operators, who drive toward practical solutions and have an ownership mindset

Truth Seekers, who are detailed, rational, and humble problem solvers

Individuals Who Inspire Excellence in themselves and those around them

High-quality executors, who execute against goals and milestones with quality, precision, and speed

Education, Experience & Skills Requirements

PhD degree in biochemistry, immunology or related life science field and 8 years of experience

Experience with antibody discovery, including antibody engineering, antibody affinity maturation, and developability

Hands-on experience with immunology skills including PBMC isolation and macrophage differentiation, ADCP / ADCC / CDC assays, multicolor flow cytometry

Hands-on experience with protein and antibody engineering skills including protein expression and purification, size exclusion chromatography, antibody campaigns and screening, BLI / SPR kinetics and epitope binning

Passion for getting lifesaving medicines into the hands of patients as quickly and efficiently as is humanly possible

Ability to handle multiple projects simultaneously

Ability to work independently and as part of a team

Must be comfortable with ambiguity

Fast (extremely fast) learner

What We Offer

Patient Days, where we are fortunate to hear directly from individuals living with the conditions we are seeking to impact throughout the year and learn how we can improve our efforts

A culture inspired by our values : put patients first, think independently, be radically transparent, every minute counts, and let the science speak

A de-centralized model that enables our program teams to focus on advancing science and helping patients. Our affiliate structure is designed to eliminate bureaucracy and put decision-making power in the hands of those closest to the science

A place where you own the vision – both for your program and your own career path

A collaborative, fast-paced, data-driven environment where we inspire ourselves and each other to always perform at the top of our game

Access to learning and development resources to help you get in the best professional shape of your life

Robust and market-competitive compensation & benefits package (Base, Performance Bonus, Equity, health, welfare & retirement programs)

Flexible PTO

Rapid career advancement for strong performers

Potential ability to work on multiple BridgeBio Pharma programs across multiple therapeutic areas over time

Commitment to Diversity, Equity & Inclusion

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Director/Senior Director, Antibody Development & Engineering San Francisco, CA/Hybrid

What are the responsibilities and job description for the Director/Senior Director, Antibody Development & Engineering San Francisco, CA/Hybrid position at BridgeBio Pharma?

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