Senior Scientist, Statistical Genetics

Working with Us
Challenging. Meaningful. Life-changing. Those aren’t words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You’ll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams rich in diversity. Take your career farther than you thought possible.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more: careers.bms.com/working-with-us.

When you join BMS, you are joining a diverse, high-achieving team united by a common mission. 

The Informatics and Predictive Sciences (IPS) mission is to Pioneer, Partner and Predict to drive transformative insights for patient benefit.  IPS conducts applied computational research in areas that include genomic, structural and molecular informatics, computational and systems biology, patient selection and translational biomarker research, and broader fields including knowledge science, epidemiology and machine learning—across the full lifecycle of drug discovery and development and across all therapeutic areas at BMS.   We do this in close partnership with scientific and clinical experts in the field, both inside and outside the company.   We perform innovative science to empower key data-driven decisions across a rich pipeline of next-generation medicines. In doing so, our work transforms the lives of patients, as well as our own lives and careers.

Here, you’ll get the chance to grow and thrive through opportunities that are uncommon in scale and scope. You’ll pursue innovative ideas while advancing professionally alongside some of the brightest minds in biopharma.

We seek a talented computational researcher to contribute to target discovery and translational efforts for neurological diseases using large-scale human genetic data. This role will sit within Informatics & Predictive Sciences, a globally distributed group driving innovative computational research for discovery and early development within BMS research.

A key focus will be identification of drug target candidates, indications, and biomarker approaches with strong causal human biology that are aligned with company strategy for neurological diseases. This will involve application of innovative statistical genetics methods that combine human genetic data with functional and clinical data (e.g., GWAS, fine-mapping, colocalization, Mendelian Randomization, rare variant associations tests, and polygenic modeling methods) to build and inform therapeutic hypotheses, including directionality, efficacy, safety, patient segmentation, and indication selection. It will also include synthesizing and communicating key findings at cross-functional target discovery meetings.

This position offers an exciting opportunity to impact human health through innovative human genomics research, and will enable discovery groups within BMS research to launch novel programs based on causal human biology. It is also an opportunity to work closely with the broader scientific community through pre-competitive collaborations (e.g. FinnGen, UK Biobank, UK Genes & Health, Alliance for Genomic Discovery), and to publish and present industry-leading work in this area.  

Location: Cambridge, MA

Responsibilities will include, but are not limited to, the following:

• Implement cross-biobank analyses focused on identifying human genetic risk factors for neurological diseases (e.g. GWAS meta-analysis, rare variant burden tests)
• Work with a team of scientists who use human genetics and complementary omics data to identify novel targets and develop therapeutic hypotheses for indications of interest in Neuroscience.
• Design and perform integrative analyses to infer causal mechanisms driving disease using human genetics and other data types (e.g. sc-RNAseq)
• Leverage disease specific datasets that are multi-modal and derived from consortia such as AMP AD, AMP PD, Answer ALS.
• Coordinate with stakeholders across research to advance novel drug targets and program strategies with human genetic data
• Communicate findings and recommend follow up actions in multiple settings (including 1:1, seminars, project meetings, and external publications)

Basic Qualifications:

• Bachelor’s Degree with 6 years of academic / industry experience
• Or
• Master’s Degree with 4 years of academic / industry experience
• Or
• PhD with 2 years of academic / industry experience

Preferred Qualifications:

• PhD in statistical genetics, neurogenetics, or a related computational/quantitative discipline field with 2 or more years of relevant postdoctoral research and/or industry experience preferred
• Deep scientific expertise in statistical genetics methods for causal inference and omics-based molecular epidemiology.
• Design and analysis of genetic association studies (case/control and progression) and integration with molecular QTLs and causal gene/variant mapping.
• Advanced hands-on knowledge of at least one high-level programming language such as R or Python
• Demonstrated ability to advance multi-disciplinary team projects required

The starting compensation for this job is a range from $101,000 - $126,000, plus incentive cash and stock opportunities (based on eligibility). The starting pay takes into account characteristics of the job, such as required skills and where the job is performed. Final, individual compensation is decided based on demonstrated experience. For more on benefits, please visit our BMS Careers site. Eligibility for specific benefits listed in our careers site may vary based on the job and location.

Benefit offerings are subject to the terms and conditions of the applicable plans then in effect and may include the following: Medical, pharmacy, dental and vision care. Wellbeing support such as the BMS Living Life Better program and employee assistance programs (EAP). Financial well-being resources and a 401(K). Financial protection benefits such as short- and long-term disability, life insurance, supplemental health insurance, business travel protection and survivor support. Work-life programs include paid national holidays and optional holidays, Global Shutdown days between Christmas and New Year’s holiday, up to 120 hours of paid vacation, up to two (2) paid days to volunteer, sick time off, and summer hours flexibility. Parental, caregiver, bereavement, and military leave. Family care services such as adoption and surrogacy reimbursement, fertility/infertility benefits, support for traveling mothers, and child, elder and pet care resources. Other perks like tuition reimbursement and a recognition program.  

If you come across a role that intrigues you but doesn’t perfectly line up with your resume, we encourage you to apply anyway. You could be one step away from work that will transform your life and career.

Uniquely Interesting Work, Life-changing Careers
With a single vision as inspiring as “Transforming patients’ lives through science™ ”, every BMS employee plays an integral role in work that goes far beyond ordinary. Each of us is empowered to apply our individual talents and unique perspectives in an inclusive culture, promoting diversity in clinical trials, while our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.

On-site Protocol

BMS has a diverse occupancy structure that determines where an employee is required to conduct their work. This structure includes site-essential, site-by-design, field-based and remote-by-design jobs. The occupancy type that you are assigned is determined by the nature and responsibilities of your role:

Site-essential roles require 100% of shifts onsite at your assigned facility. Site-by-design roles may be eligible for a hybrid work model with at least 50% onsite at your assigned facility. For these roles, onsite presence is considered an essential job function and is critical to collaboration, innovation, productivity, and a positive Company culture. For field-based and remote-by-design roles the ability to physically travel to visit customers, patients or business partners and to attend meetings on behalf of BMS as directed is an essential job function.

BMS is dedicated to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace accommodations/adjustments and ongoing support in their roles. Applicants can request a reasonable workplace accommodation/adjustment prior to accepting a job offer. If you require reasonable accommodations/adjustments in completing this application, or in any part of the recruitment process, direct your inquiries to adastaffingsupport@bms.com. Visit careers.bms.com/eeo-accessibility to access our complete Equal Employment Opportunity statement.

BMS cares about your well-being and the well-being of our staff, customers, patients, and communities. As a result, the Company strongly recommends that all employees be fully vaccinated for Covid-19 and keep up to date with Covid-19 boosters.

BMS will consider for employment qualified applicants with arrest and conviction records, pursuant to applicable laws in your area.

If you live in or expect to work from Los Angeles County if hired for this position, please visit this page for important additional information: https://careers.bms.com/california-residents/

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