What are the responsibilities and job description for the Intern, Cell Biology - Cell cycle-dependent lysosome dynamics (MS/PhD) position at Calico Life Sciences?
Position Description
Calico is seeking an intern to join the Gottschling Lab. To succeed, you will need to be an enthusiastic team player, detail-oriented, extremely organized and comfortable working on complex problems. In this position you will study the dynamics of the lysosome in mammalian cell lines. The successful candidate will use live cell microscopy and immunofluorescence to characterize pH regulation in the lysosome during the mitotic cell cycle, and during cell cycle exit upon differentiation.
Responsibilities
Calico’s internship program is a paid 12-week program over the summer for students interested in understanding the fundamental science of aging and finding treatments for the associated and intractable diseases. Working in a collaborative environment and fully embedded in one of our labs/teams, Calico interns tackle a unique project under the mentorship of at least one of our scientists or engineers. Students from all schools, and students who identify with a demographic that is underrepresented within the technology, data science, and healthcare industries are encouraged to apply. This includes but is not limited to Black, Latinx, Native American, students with disabilities, veterans, and non-binary people.
Program Features
Calico is seeking an intern to join the Gottschling Lab. To succeed, you will need to be an enthusiastic team player, detail-oriented, extremely organized and comfortable working on complex problems. In this position you will study the dynamics of the lysosome in mammalian cell lines. The successful candidate will use live cell microscopy and immunofluorescence to characterize pH regulation in the lysosome during the mitotic cell cycle, and during cell cycle exit upon differentiation.
Responsibilities
- Generate mammalian cell lines expressing recently developed fluorescent reporters and establish conditions for time resolved, high content microscopy
- Characterize the dynamics of lysosomal pH in different cell cycle stages and cellular states
- Characterize cellular signaling pathways and regulatory principles previously implicated in lysosomal dynamics
- Currently pursuing a Master’s (MS) or PhD or degree in Cell Biology, Biochemistry or a related field
- Experience with mammalian tissue culture including the generation of cell lines using viral vectors
- Experience with wide field microscopy, ideally with time lapse analysis.
- Detail-oriented and organized
- Strong teamwork and communication skills
- Self-motivated with a “can-do” attitude
- Flexible, able to respond quickly to shifting priorities and able to multitask
- Available to work for the summer months in person at our location in South San Francisco, CA
- Good understanding of nutrient sensing pathways and metabolic regulation
Calico’s internship program is a paid 12-week program over the summer for students interested in understanding the fundamental science of aging and finding treatments for the associated and intractable diseases. Working in a collaborative environment and fully embedded in one of our labs/teams, Calico interns tackle a unique project under the mentorship of at least one of our scientists or engineers. Students from all schools, and students who identify with a demographic that is underrepresented within the technology, data science, and healthcare industries are encouraged to apply. This includes but is not limited to Black, Latinx, Native American, students with disabilities, veterans, and non-binary people.
Program Features
- 3-month summer timeline
- In-person experience at our offices in South San Francisco
- Matching with at least one Calico mentor
- Group supplemental activities weekly featuring guest speakers, Senior Leadership spotlights, and discussion groups on aging science, our drug development approach, and more
- End-of-summer company-wide project showcase and poster session
- Competitive compensation ($40 - $65/hour) and monthly living expenses stipend
- Able to work in-person at our offices in South San Francisco
- Free for a consecutive period of 11-12 weeks in June, July, and August
- Not graduating before December 2025
- Exception for students enrolling into a graduate degree program in Fall 2025
- Must be enrolled in a US university
Salary : $40 - $65
