Senior Chemist I

Cambridge Isotope Laboratories, Inc. (CIL) is searching for a Senior Chemist I based onsite in our Andover, MA facility.  CIL is the global leading company in a highly technical, extremely fast-growing industry and is a critical supplier to several scientific and high technology markets.  CIL's growing customer base spans academia, pharmaceutical, medical diagnostic and semiconductor industries enabling collaborations with Nobel laureates, industry-leading scientists, and chemists. CIL partners with leading instrument manufacturers as well pioneering research groups that have expertise in product development and drive market growth. CIL is a subsidiary of the Otsuka Pharmaceutical Group and has had consistent growth for over 40 years.

The Senior Chemist I will be responsible for the de novo synthesis, route development, and final product characterization of a wide variety of complex isotopically labeled targets (13C, 15N, 18O, and D isotopes). This role demands the production of high-quality, finished products in accordance with established specifications, while adhering to CIL’s safety and general policies. The Senior Chemist I will operate with a high degree of autonomy, ensuring that production requirements for safety, yield, time, and quality are consistently met.

Responsibilities

• Adhere to CIL’s general and safety policies to maintain a safe work environment
• Synthesize complex, non-routine, and routine target compounds containing isotopes such as 15N, 18O, D, and/or 13C, utilizing established SOPs where applicable
• Design and develop new synthetic routes when required to achieve optimal results
• Contribute to the optimization of chemical processes for targeted molecules, intermediates, and scalable, cost-effective production methods
• Analyze and interpret data using various techniques, including Nuclear Magnetic Resonance (NMR), Ultraviolet (UV) Spectroscopy, Mass Spectrometry (MS), High-Performance Liquid Chromatography (HPLC), and Infrared (IR) Spectroscopy
• Employ a variety of purification techniques, including chromatography, distillation, recrystallization, and sublimation
• Maintain accurate and detailed records in the laboratory notebook
• Mentor and assist junior team members, offering guidance on experimental techniques and troubleshooting
• Ensure all work is conducted with strict adherence to safety protocols and good laboratory practices, in line with CIL’s safety manual
• Perform additional related duties as needed

• Ph.D. in Synthetic Organic Chemistry or a closely related field, or a Master's degree with significant relevant experience (e.g., 5 years in organic chemistry and/or synthesis)
• Alternatively, a Bachelor's degree in Chemistry or a related field with extensive hands-on experience in organic synthesis and chemical processes may be considered
• 1-3 years of professional experience in organic chemistry and/or synthesis, or equivalent practical training as a Research Assistant or Postdoctoral Researcher
• Expertise in organic synthetic methods, chemical separation, and compound identification, with strong analytical skills
• Proficiency in laboratory techniques, including synthesis, purification, and characterization of organic compounds
• Strong communication, documentation, and collaboration skills
• Ability to perform hands-on bench chemistry, which may involve standing, bending, and stooping
• Familiarity with working in a controlled, hooded lab environment, as required by safety protocols
• Comfortable working with both hazardous and non-hazardous chemicals
• Physical ability to lift 50 lbs regularly and transport drums of chemicals, including up to 55-gallon drums, using appropriate equipment (e.g., drum dolly)

CIL and CIS offer a competitive salary and comprehensive benefits including generous paid time off, Long Term Incentives, 6% matching 401K plan and health insurance with no in-network deductible.

Cambridge Isotope Laboratories is an Equal Opportunity Employer.

Learn more about us on our website: www.isotope.com

About Us:

Cambridge Isotope Laboratories, Inc. (CIL) is the world’s leading producer of stable isotopes and stable isotope-labeled compounds. With approximately 750 employees and laboratories in four countries, CIL specializes in the process of labeling biochemical and organic compounds with highly enriched, stable (nonradioactive) isotopes of carbon, hydrogen, nitrogen and oxygen. Our chemists substitute common atoms (e.g., 1H, 12C, 14N, 16O) with rare, highly valued isotopes (e.g., 2H or D, 13C, 15N, 18O) so that the final product can be readily measured or traced using mass spectrometry (MS) or nuclear magnetic resonance (NMR). CIL’s products are utilized in laboratories, medical, government and academic research centers and health care facilities worldwide.

We are proud that CIL products have contributed to medical advancements in cancer research, new-drug development, environmental analysis, and medical diagnostic research. In the past decade, as the fields of proteomics and metabolomics have developed as leading techniques for determining biomarkers for disease presence, progression and the monitoring of therapeutic response, CIL has worked closely with industry leaders and researchers to provide the stable isotope-labeled tools needed for improved quantitation and qualification of complex biological systems.

After decades of research, stable isotopes have found their place in an ever expanding commercial scale applications in pharmaceuticals, semiconductors, flat panel displays as well as other high technology fields specifically with deuterium oxide (D2O) and deuterium gases. Pharmaceutical companies have begun to investigate deuteration of molecules that may provide advantages over their existing nondeuterated counterparts. In addition, increasing research into the potential medical advantages of new deuterated drugs is also occurring. In high technology, deuterated organic molecules and deuterium gas are commonly used in the manufacturing of microelectronics and OLEDs, which contribute to the increased lifetime of the devices.

Learn more about us on our website: www.isotope.com