Postdoctoral Scientist - Omar Lab - Computational Biomedicine

Principal Investigator, Daniel Berman, MD is looking for a Postdoctoral Scientist to join the team!

When the work you do every single day has a crucial impact on the lives of others, every effort, every detail, and every second matters. This shared culture of happiness, passion, and dedication pulses through Cedars-Sinai, and it’s just one of the many reasons why we rank as one of the top hospitals in the nation by U.S. News & World Report.

The Omar Lab at Cedars-Sinai focuses on developing robust artificial intelligence (AI)-powered multimodal risk-stratification tools to forecast the risk of disease progression in cancer patients. These tools incorporates the composition of the tumor microenvironment in their training to improve their robustness, accuracy, and generalizability to different patient cohorts.

We are seeking a wet lab-focused postdoctoral scientist with expertise in cancer molecular biology to work on a fully-funded project aiming to investigate the mechanisms underlying bone metastasis in prostate cancer. This project leverages state-of-the-art high-resolution spatially resolved multiomics profiling of tissue samples from genetically engineered mouse models and human patients to characterize the molecular and spatial interactions between different cell types in the microenvironments of both the primary tumor and bone at different disease stages.

Are you ready to be a part of breakthrough research?

The ideal candidate will have experience in utilizing single cell and spatial omics to decipher the cellular composition of the tumor and bone microenvironments during disease progression from localized to locally-advanced and metastatic stages. Characterizing the different cell types and interactions mediating such transitions. The ideal candidate may also have strong experience in genetically-engineered mouse models of prostate cancer, and should be proficient in the handling of tissue specimens, data collection, and interpretation (spatial transcriptomics and proteomics). They may also be skilled in the computational analysis of such data using standard libraries such as Seurat, Scanpy, Squidpy, etc. Competitive candidates will have experience publishing at least one first author paper in the mentioned disciplines as a graduate student.

Working independently but in close cooperation and in consultation with the Dr. Berman and other Research Scientists, the Postdoctoral Scientist will perform routine and complex laboratory procedures throughout training period. May develop, adapt, and implement new research techniques and protocols. Analyzes and interprets data. May assist in preparation of grant proposals. Participates in publications and presentations as author or co-author. Not responsible for generating grant funds.

Primary Job Duties and Responsibilities:

• May assist in the preparation of grant proposals, but is not responsible for generating grant funds.
• May participate in publications and presentations as author or co-author.
• Designs and performs experiments. Will keep appropriate experimental records and documentation and analyze the results with the Principal Investigator.
• May develop, adapt, and implement new research techniques and protocols.
• Analyzes, interprets, summarizes, and compiles data.
• Performs routine and complex laboratory procedures throughout the training period.
• Operates and maintains equipment and instruments.
• May observe MD-patient or MD-human research subject interactions as it pertains directly to research being performed.

Education:

• Doctorate (MD, PhD, VMD, or DDS) in the area directly related to the research specialization field is required.

Experience and Skills:

• Highly motivated and works independently on research projects designed by a mentor (typically the PI) within the area of specialization.
• Acquires thorough technical and theoretical knowledge of research projects and objectives during one to five (1-5) year post-doctoral appointment.
• Demonstrated aptitude to perform experimental protocols and procedures, including detailed data collection, analysis, and specialized equipment operation and maintenance.
• Knowledge of safety standards and maintenance of specialized equipment.