What are the responsibilities and job description for the Director, Protein Biochemistry/Drug Discovery (NJ) position at CHDI Management?
Job Description
Job Description
Job Posting
Title : Scientific Director : Protein Biochemistry / Drug Discovery
Reports directly to the Vice President Preclinical Drug Discovery
Location : Los Angeles, CA or Princeton, NJ / currently hybrid
Vaccination against COVID-19 is a prerequisite for employment at CHDI Management.
About CHDI
CHDI Foundation, Inc. is a privately funded, nonprofit, biomedical research organization that is exclusively dedicated to rapidly accelerating therapies that slow the progression of Huntington’s disease (HD). Our scientists work closely with a network of more than ~700 researchers in academic and industrial laboratories around the world in the pursuit of these novel therapies, providing strategic scientific direction to ensure that our common goals remain in focus. This helps bridge the translational gap that often exists between academic and industrial research pursuits and that adds costly delays to therapy development. In our role as a collaborative enabler, CHDI seeks to bring the right partners together to identify, address, and de-risk critical scientific issues to accelerate drug candidates to clinical evaluation as rapidly as possible. Our activities extend from exploratory biology to the identification and validation of therapeutic targets and the development of proof-of-concept compounds, as well as to provide support for clinical studies and trials.
Our staff works for CHDI Management, Inc. CHDI Management provides administrative, management, and contracting services to CHDI Foundation, as well as to other non-profit organizations dedicated to HD research.
Job Role
CHDI Management seeks an experienced, innovative, and passionate drug discovery scientist to join the preclinical team as Science Director, to support the Foundation’s mission to accelerate meaningful therapies and clinical biomarkers for Huntington’s disease. In this role you will be responsible for developing and coordinating the strategy and tactics for protein biochemistry / biophysics related core platforms in support of target validation and target modulator mechanistic studies. You will participate in interdisciplinary teams with goals, strategies and objectives to advance a portfolio of drug discovery campaigns to elaborate proof of concept / mechanism compounds. You will participate in identifying, evaluating, advising, and partnering on external programs, technologies, and modalities that are relevant to our mission. The position involves being a team member along with a group of highly experienced group of scientists within CHDI, as well as coordination / oversight of a larger team of external experts and collaborators (CROs and academics) within a unique “virtual” biopharmaceutical research model. A strong commitment to help patients coupled with scientific excellence, and commitment to collaborating, engaging and empowering diverse scientists is essential. CHDI Foundation conducts their research from three USA-based offices (New York City, Los Angeles, & Princeton). The position requires regular travel between the CHDI offices and to the various CROs and academics located in the USA, EU, and Britain.
Job Description
- Provide expertise on how proteins (specifically “molecular machines”) work at biochemical, mechanistic, and cell-based levels.
- Provide expertise in mechanistic enzymology. Lead and oversee the design, development and deployment of biochemical and biophysical assays that inform on protein structure-function and options to modulate their activities and functions.
- Provide expertise in protein production and qualification. Contribute to structure-function studies to inform on mechanistic activities, phenocopy pharmacology and help guide structure-activity relationships.
- Oversee designing and implementing biochemical and biophysical assays to inform on protein function, protein dynamics, and ligand interactions (e.g., SPR, SEC-MALS, MST, NanoDSF, NMR-spectroscopy, stop-flow EPR, Molecular Dynamics, etc.)
- Provide expertise in detailed mechanistic enzyme kinetics to aid in the design and prosecution of assays to effectively profile both reversible and irreversible modulators and to gain insight into the mechanism of action and structure activity relationships for drug efficacy.
- Provide biochemistry perspective as part of a multi-disciplinary drug discovery team that includes computational chemistry, structural biology, medicinal chemistry, and genetics and cell biology expertise.
Job requirements
Salary range : $120,000-220,000. Exact compensation will vary based on experience.
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Salary : $120,000 - $220,000
