Demo

Principal Scientist/Associate Director, CNS Biology

City Therapeutics
Cambridge, MA Full Time
POSTED ON 3/27/2025
AVAILABLE BEFORE 4/25/2025
City Therapeutics is seeking a CNS Project Lead. The selected candidate will drive the project team by managing internal cross-functional and external collaborations. This role will lead the identification of siRNA leads for CNS target(s), contribute to platform strategy and new target evaluations. Please note this is an on-site opportunity.

Responsibilities

  • Oversee efforts to identify candidate siRNAs for lead CNS target(s)
  • Develop and manage project plan to progress candidate siRNAs from discovery to development candidate
  • Collaborate with computational biology, screening, platform and in vivo pharmacology functions to advance project
  • Manage research including engagement and oversight of CROs
  • Lead cross-functional working group to enable and execute the project plan
  • Participate in the assessment of new platform technologies

Qualifications

  • PhD in biology, pharmacology, biochemistry or related field with 8-10 years of experience or MS degree with 12 years of experience
  • Direct CNS disease biology experience strongly preferred
  • Experience with CRO engagement and oversight to execute studies
  • Experience with external academic or industry collaborators
  • Oligonucleotide experience preferred (siRNA, ASO, mRNA)
  • Track record of success leading cross-functional teams to drive scientific results
  • Excellent communication skills and ability to work in a nimble and innovative environment

City Therapeutics is accepting resumes/CVs from direct applicants only. Recruitment Agency submissions will not be accepted at this time.

City Therapeutics is an Equal Opportunity and Affirmative Action employer committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.

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