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Sr. Research Associate - In Vivo Pharmacology

City Therapeutics
Cambridge, MA Full Time
POSTED ON 2/24/2025
AVAILABLE BEFORE 5/23/2025

The Senior Research Associate, In Vivo Pharmacology role will play a key role in advancing City's platform technology and screening potential siRNA therapeutics in vivo. The Associate will be responsible for executing in vivo studies by dosing animals, harvesting tissues, and performing downstream analysis of tissues to evaluate drug potency.

Responsibilities :

  • Execute in vivo studies by dosing animals, monitoring body weights, performing euthanasia, and harvesting tissues
  • Assist in advanced surgical procedures
  • Perform downstream molecular analysis of tissues by RT-qPCR, western, and / or ELISA
  • Work collaboratively in a multi-team environment
  • Present findings in program team and company-wide meetings

Qualifications :

  • B.S. in Biology or related field plus 2-5 years' experience working with mice and / or rats
  • Ability to dose mice and / or rats IV, SC, and IP
  • Blood collection by submental, cheek bleed, and / or cardiac puncture
  • Experience performing necropsy and tissue collection
  • Experience performing ex vivo analysis techniques such as RNA and protein isolation, RT-qPCR, western blot, and / or ELISA
  • Experience using anesthesia (ketamine or isoflurane) and aseptic technique
  • Strong record keeping skills
  • City Therapeutics is accepting resumes / CVs from direct applicants only. Recruitment Agency submissions will not be accepted at this time.

    City Therapeutics is an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, age, sexual orientation, gender identity, disability, veteran status, or any other classification protected by law.

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