Demo

Principal Scientist, Analytical Chemistry

Confidential Careers
Philadelphia, PA Contractor
POSTED ON 4/1/2025
AVAILABLE BEFORE 4/30/2025

Principal Scientist, Analytical Chemistry – Philadelphia, PA

The Principal Scientist role is a multifunctional, in-lab, hands-on position.

The selected candidate will take a lead role in execution of analytical programs. He/she will design and develop studies to advance and progress the expertise and capabilities in the nanoparticle innovation space. Results of research/progress will be communicated regularly to executive leadership.

Job Responsibilities

  • Willingly and enthusiastically work at the bench to solve analytical challenges encountered within drug development.
  • Can be relied upon to work independently and develop a variety of analytical methods in-house or in collaboration with contract organizations for starting materials, intermediates, and final drug products, including but not limited to GPC, HIC, Ion Exchange Chromatography, Size Exclusion Chromatography (SEC), UPLC/HPLC, RP-HPLC, LC-MS, MS, High Resolution Mass Spectroscopy (HRMS), MALDI-TOF, GC-FID, KF, Field Flow Fractionation, FFF-MALS-DLS, Asymmetric Flow Field AF-MALS, NMR, SERS, XPS, TGA, DSC, DLS, Zeta Potential, UV-vis, ELISA, TEM, AFM, Fluorimetry, Endotoxin Testing, BET, LAL, Flow Cytometry, Infrared (IR) and Raman Spectroscopy, FTIR, SDS-PAGE and Gel Electrophoresis.
  • Assess existing analytical methods and identify areas for further improvements and optimization.
  • Perform new analytical method development, qualification and validation and support the technology transfer of analytical methods.
  • Ability to bring analytical methods developed at CROs/CDMOs in-house.
  • When required, perform routine chemical/physical testing of raw materials, in-process, finished product and stability samples according to in-house methods and compendial methods as applicable, generating reliable and interpreting data in support of clinical studies.
  • Prepare and review analytical method protocols, reports and SOPs, as required.
  • Other duties as assigned.

Required Skills and Competencies and Education

  • Demonstrated/proven abilities to develop, optimize, and validate analytical methods and testing procedures.
  • Gold Nanoparticle, Nanoparticle, LNP, Biologics, Proteins, Small Molecules, Large Molecules experience.
  • Demonstrated expertise in creating chromatographic methods for purity, impurities, surface chemistry and charge, surface homogeneity, size and ligand distributions, chemical bonding, and integrity for synthetic large molecule PEGylated nanoparticles is highly preferred.
  • Excellent communications skills with demonstrated ability to communicate clearly in English in both written and spoken form.
  • Excellent data analysis, plotting, summary and presentation skills.
  • Demonstrated ability to work on multiple projects in parallel in collaboration with outside vendors and internal research teams.
  • Experience in collaborating analytical CROs/CDMOs and the ability to work one-on-one with the counterparts in these contract organizations.
  • An advanced degree in analytical chemistry or relevant field is highly preferred. Bachelor’s degree with significant industry experience will be considered.
  • 5-10 years of previous industry experience is required.

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