What are the responsibilities and job description for the Scientist 1, Chemistry position at Crinetics Pharmaceuticals, Inc.?
Crinetics is a pharmaceutical company based in San Diego, California, developing much-needed therapies for people with endocrine diseases and endocrine-related tumors. We were founded by a dedicated team of scientists with the simple belief that better therapies developed from rigorous innovation can lead to better lives. Our work continues to make a real difference in the lives of patients. We have a prolific discovery engine and a robust preclinical and clinical development pipeline. We are driven by science with a patient-centric and team-oriented culture. Crinetics is known for its inclusive workplace culture. We are also a dog-friendly workplace. This is an exciting time to join Crinetics as we shape our organization into the world’s premier fully integrated endocrine company from discovery to patients. Join our team as we transform the lives of others.
Position Summary:
The Scientist 1, will be responsible for contributing to the success of Crinetics’ growing drug discovery projects and working within the chemistry team. This individual will be responsible for both the design and synthesis of small-molecule drug candidates and should be highly proficient in the analysis of diverse data sets to build/drive Crinetics's medicinal chemistry strategy. This role would be onsite based in our San Diego headquarters.
Essential Job Functions and Responsibilities:
These may include but are not limited to:
Independently design, plan, and execute the synthesis, purification, and submission of small molecule drug candidates and other molecules.
Troubleshoot chemistry problems independently.
Generate effective hypotheses to pursue, followed by experimental planning and execution.
Prepare and organize data for presentations and be able to present written and oral reports within the team and cross-functionally.
Participate in group discussions to exchange ideas among peers.
Prioritize chemistry efforts to ensure efficient and timely progression of projects to meet company goals.
Contribute to the day-to-day running of the lab to ensure a smooth and safe operation.
Conducted and coordinated lab tasks and responsibilities to ensure a smooth and safe operation.
Stay current in synthetic organic and medicinal chemistry literature to support the company's research objectives.
Education and Experience:
Ph.D. in synthetic organic chemistry
Highly skilled in methodology development and multistep synthesis with demonstration of excellent problem-solving skills.
Strong track record of achievement in synthesizing complex molecules with state-of-the-art knowledge of modern synthetic methodologies and analytical and purification techniques.
Proven track record of creative thinking and consistent delivery as demonstrated by patent/publication/presentation record.
Excellent written and oral communication skills, enthusiasm, integrity, self-motivation, strong interpersonal skills, and ability to interact within a multidisciplinary team.
Responds well to scientific challenges and applies significant rigor to their own work.
Proficient in using chemistry-related software and databases such as ChemDraw, SciFinder, Reaxys.
Lab oratory experience with: Flash column systems, NMR spectroscopy, thin layer chromatography, handling pyrophoric materials, and LC/MS.
Technical Knowledge Required:
Office software knowledge: Windows, MS Office (Outlook, Word, PowerPoint, Excel).
Chemistry-related software required: ChemDraw, Electronic notebooks, NMR analysis.
Office equipment: PC, scanners, voice mail and e-mail systems, and common office machines or the ability to be trained.
Physical Demands and Work Environment:
Physical Activities: On a continuous basis, sit at a desk for a long periods of time; intermittently answer telephone and write or use a keyboard to communicate through written means. Some walking and lifting to 25 lbs. may be required. The noise level in the work environment is typically low to moderate. The physical demands described above are representative of those that must be met by an employee to successfully perform the essential functions and responsibilities of this job. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions and responsibilities.
Laboratory Activities (if applicable): Biology and chemical laboratory environment experience needed. Environmental health and safety requirements also apply.
Travel:
You may be required to travel for up to 5% of your time.
The Anticipated Base Salary Range: $107,000 - $133,000
In addition to your base pay, our total rewards program consists of a discretionary annual target bonus, stock options, ESPP, and 401k match. We also provide top-notch health insurance plans for employees (and their families) including medical, dental, vision, and basic life insurance, 20 days of PTO, 10 paid holidays, and a winter company shutdown.
The final salary offered to a successful candidate will be dependent on several factors that may include but are not limited to the type and length of experience and education. Crinetics Pharmaceuticals is a multi-state employer, and this salary range may not reflect positions that work in other states. Your recruiter can share more about the specific salary range during the hiring process.
Equal Opportunity Employer:
Crinetics is proud to be an Equal Opportunity Employer. We provide equal employment opportunities to all employees and employment applicants without regard to unlawful considerations of sex, sexual orientation, gender (including gender identity and/or expression), pregnancy, race, color, creed, national or ethnic origin, citizenship status, religion or similar philosophical beliefs, disability, marital and civil union status, age, genetic information, veteran status or any personal attribute or characteristic that is protected by applicable local, state or federal laws.
Vaccination requirement:
Following extensive monitoring, research, consideration of business implications, and advice from internal and external experts, Crinetics requires that all employees and contractors be fully vaccinated and have received the COVID-19 vaccines as a condition of employment. “Full vaccination” is defined as two weeks after both doses of a two-dose vaccine or two weeks after a single-dose vaccine has been administered. Anyone unable to be vaccinated, either because of a sincerely held religious belief or a medical condition or disability that prevents them from being vaccinated, can request a reasonable accommodation.
Salary : $107,000 - $133,000
