Scientist 1, In Vitro Pharmacology

Crinetics is a pharmaceutical company based in San Diego, California, developing much-needed therapies for people with endocrine diseases and endocrine-related tumors. We were founded by a dedicated team of scientists with the simple belief that better therapies developed from rigorous innovation can lead to better lives. Our work continues to make a real difference in the lives of patients. We have a prolific discovery engine and a robust preclinical and clinical development pipeline. We are driven by science with a patient-centric and team-oriented culture. This is an exciting time to join Crinetics as we shape our organization into the world’s premier fully-integrated endocrine company from discovery to patients. Join our team as we transform the lives of others.

Position Summary:

A highly motivated Scientist 1, Targeted Therapeutics within the Biology group at Crinetics works within a highly collaborative group focusing on targets linked to unmet needs in endocrine-related cancers. The Scientist 1 participates in discovery and translational efforts aimed at identifying and characterizing novel targeted therapeutic targets. This individual will investigate the mechanisms of action of new molecules and define optimal drug profiles in vitro by designing and executing experiments under the tutelage of a senior member of the group with minimal oversight. The incumbent works in a dynamic environment to help advance programs from discovery into development as part of a multidisciplinary team.

Essential Job Functions and Responsibilities:

These may include but are not limited to:

• Ability to develop and maintain multiple stable cell lines independently.
• Implements excellent aseptic technique required for primary cell culture.
• Design, optimize, and validate pharmacology assays.
• Perform, analyze, and interpret assays independently.
• Possess knowledge of molecular biology techniques to support cell line generation.
• Maintains electronic laboratory notebooks in a timely and accurate manner.
• Aid in preparation of written technical reports and summaries independently.
• Write excellent standard operating protocols.
• Interact with other Discovery groups effectively.
• Support the organization in maintaining a work environment focused on scientific integrity and quality, one that fosters learning, open communication, collaboration, and teamwork.

Education and Experience:

Required:

• MS with 8 years or PhD with 1 year of relevant laboratory experience (industry experience preferred).
• Strong cell culture expertise with proven experience in cell line development
• Experience with basic molecular biology techniques using DNA, RNA, and protein.
• Detail-oriented, with excellent organization and record-keeping skills.
• Capable of working both independently with minimal oversight and in a collaborative environment.
• Outstanding written and oral presentation capabilities,
• Software knowledge in Windows, MS Office (Outlook, Word, Excel, PowerPoint, SharePoint, Teams), GraphPad Prism, among others as required.

Preferred:

• Experience in assay development.
• Experience in siRNA design and delivery.
• Extensive experience in developing cancer therapeutics

Physical Demands and Work Environment:

Physical Activities: On a continuous basis, sit at desk for a long period of time; intermittently answer telephone and write or use a keyboard to communicate through written means. Some walking and lifting up to 25 lbs. may be required. The noise level in the work environment is typically low to moderate. The physical demands described above are representative of those that must be met by an employee to successfully perform the essential functions and responsibilities of this job. Reasonable accommodations may be made to enable individuals with disabilities to perform essential functions and responsibilities.

Laboratory Activities (if applicable): Biology and chemical laboratory environment experience needed. Environmental health and safety requirements also apply.

Travel:

You may be required to travel for up to 5% of your time.

The Anticipated Base Salary Range: $96,000-$119,000

In addition to your base pay, our total rewards program consists of a discretionary annual target bonus, stock options, ESPP, and 401k match. We also provide top-notch health insurance plans for employees (and their families) to include medical, dental, vision, and basic life insurance, 20 days of PTO, 10 paid holidays, and a winter company shutdown.

The final salary offered to a successful candidate will be dependent on several factors that may include but are not limited to the type and length of experience and education. Crinetics Pharmaceuticals is a multi-state employer, and this salary range may not reflect positions that work in other states. Your recruiter can share more about the specific salary range during the hiring process.

Equal Opportunity Employer:

Crinetics is proud to be an Equal Opportunity Employer. We provide equal employment opportunities to all employees and employment applicants without regard to unlawful considerations of sex, sexual orientation, gender (including gender identity and/or expression), pregnancy, race, color, creed, national or ethnic origin, citizenship status, religion or similar philosophical beliefs, disability, marital and civil union status, age, genetic information, veteran status or any personal attribute or characteristic that is protected by applicable local, state or federal laws.

Vaccination requirement:

Following extensive monitoring, research, consideration of business implications, and advice from internal and external experts, Crinetics requires that all employees and contractors be fully vaccinated and have received the COVID-19 vaccines as a condition of employment. “Full vaccination” is defined as two weeks after both doses of a two-dose vaccine or two weeks since a single-dose vaccine has been administered. Anyone unable to be vaccinated, either because of a sincerely held religious belief or a medical condition or disability that prevents them from being vaccinated, can request a reasonable accommodation.