Research Associate II/Senior Research Associate, In-Vivo Editing, CRISPR-X

Company Overview

Since its inception over a decade ago, CRISPR Therapeutics has transformed from a research-stage company advancing programs in the field of gene editing, to a company with a diverse portfolio of product candidates across a broad range of disease areas including hemoglobinopathies, oncology, regenerative medicine, cardiovascular and rare diseases. The Nobel Prize-winning CRISPR science has revolutionized biomedical research and represents a powerful, clinically validated approach with the potential to create a new class of potentially transformative medicines. To accelerate and expand its efforts, CRISPR Therapeutics has established strategic partnerships with leading companies including Bayer and Vertex Pharmaceuticals. CRISPR Therapeutics AG is headquartered in Zug, Switzerland, with its wholly-owned U.S. subsidiary, CRISPR Therapeutics, Inc., and R&D operations based in Boston, Massachusetts and San Francisco, California, and business offices in London, United Kingdom.

Position Summary

We are seeking a highly motivated and talented in-vivo Research Associate II / Senior Research Associate to grow our diverse, innovation-focused CRISPR-X team that pioneers novel gene editing therapies for human disease. As part of CRISPR Therapeutics, a leading gene editing company, the candidate will be exposed to a broad clinical portfolio. The candidate will play an integral role in evaluating and advancing the next generation of genome editing modalities and genetic therapies for a wide range of human indications. The position requires enthusiasm, passion, excellent in-vivo animal skills, attention to detail, and a desire to create new medicines for patients.

Responsibilities

• Responsible for in-vivo research and execution across our next-generation modalities, covering hepatic and extra-hepatic target tissues. Design, execute and interpret in-vivo research pertaining to discovery pipeline and preclinical projects.
• Conduct hands-on research requiring in-vivo biology methods including generation, breeding, and maintenance of genetically engineered mouse models; intravenous tail-vein injection and animal surgery techniques; assessment of biomarkers and editing outcomes; longitudinal study of animal health, disease markers, and phenotypic assays; post-mortem preparation of tissue sections and IHC.
• Maintain lab notebooks and data in a highly organized manner.
• Analyze and present experimental data within the CRISPR-X team and cross-functionally.

Minimum Qualifications

• BS/MS in Biology, Veterinary Science or related discipline
• Experience:
  • Research Associate II – 2 to 4 years of relevant research experience or 0-2 years with advanced degree
  • Senior Research Associate – 5 to7 years of relevant research experience or 2-5 years with advanced degree
• Excellent technical skills for rodent (mouse and rat) in-vivo work comprising but not limited to IV injections, survival blood collection techniques, necropsy and tissue collection.
• Understanding of rodent (mouse and rat) in-vivo techniques ranging from surgical procedures on neonates to physiological and pathological assessment of diseased adult rodents.
• Familiarity with in-vivo gene editing, including applying and developing next generation gene editing technologies, such as prime editing, base editing, recombinases and retrotransposons, in an academic and/or industry setting.
• Collaborative mindset and ability to partner well with team members cross-functionally

Preferred Qualifications

• Knowledge and experience in advanced in vivo techniques such as hepatectomies, liver perfusion and hepatocyte isolation, lung function assays and pre-natal treatments.

Competencies

• Collaborative – Openness, One Team
• Undaunted – Fearless, Can-do attitude
• Results Orientation – Delivering progress toward our mission. Sense of urgency in solving problems.
• Entrepreneurial Spirit – Proactive. Ownership mindset.

Due to the nature of their work, our manufacturing and lab-based positions are located fully on-site.

CRISPR Therapeutics, Inc. is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, gender, age, religion, national origin, ancestry, disability, veteran status, genetic information, sexual orientation or any characteristic protected under applicable law.

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