Chief Medical Officer (CMO) | Immuno-Oncology

Chief Medical Officer (CMO) | Immuno-Oncology | Cambridge, MA

Location : Cambridge, MA (Hybrid / Flexible)

Salary : Competitive base bonus equity

Sector : Biotechnology | Clinical Development | Immuno-Oncology

Job Type : Full-time | Permanent

Job Description

A high-growth VC-backed biotech specializing in Immuno-Oncology is seeking a Chief Medical Officer (CMO) to lead clinical and regulatory strategy , driving the development of cutting-edge IO therapies from IND through regulatory approval .

This is a unique opportunity for a clinical development leader to shape the success of a pioneering biotech at the forefront of immune-based cancer therapeutics .

Key Responsibilities

• Define and oversee the clinical development strategy for a first-in-class IO pipeline .
• Lead IND, CTA, and regulatory filings , engaging with FDA, EMA, and global health authorities .
• Direct Phase I-III clinical trials , ensuring scientific and operational excellence.
• Collaborate with R&D and translational medicine teams to optimize biomarker-driven trial design.
• Represent the company at scientific conferences, investor meetings, and key industry events .
• Partner with BD and Commercial teams on strategic partnerships and future market planning.

Candidate Profile

Why Apply?

Lead the development of cutting-edge Immuno-Oncology therapeutics.

Equity participation in a high-potential biotech with strong investor backing.

Strategic Impact - Drive the success of a transformative IO pipeline .

Desired Skills and Experience

MD (or MD / PhD) with 15 years of experience in clinical development.

Extensive experience in Immuno-Oncology drug development, including checkpoint inhibitors, cell therapies, or novel IO approaches.

Proven track record of advancing oncology assets from early-phase trials through regulatory approval.

Strong experience in regulatory interactions (FDA, EMA) and global trial execution.

Ability to thrive in a VC-backed, high-growth biotech environment.