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Principal Scientist, Translational Medicine

Denali Therapeutics Inc
South San Francisco, CA Full Time
POSTED ON 2/13/2025
AVAILABLE BEFORE 4/13/2025

Neurodegenerative diseases are one of the largest medical challenges of our time. Denali Therapeutics is a biotechnology company dedicated to developing breakthrough therapies for neurodegenerative diseases through our deep commitment to degeneration biology and principles of translational medicine. Denali is founded on the collaboration of leading scientists, industry experts, and investors who share the vision that scientific discovery energetically applied to translational medicine is the key to delivering effective therapies to patients.

We invite you to consider an opportunity with Denali to help achieve our goal of delivering meaningful therapeutics to patients.

Key Accountabilities/Core Job Responsibilities:

  • Perform research in a dynamic and collaborative environment.

  • Initiate/lead complex projects and collaborate cross-functionally and/or externally.

  • Mentor more junior scientists in the lab and on project teams.

  • Define biomarker strategies that can deliver clinical evidence of target engagement, pathway engagement and modulation of disease biomarkers in clinical development plans.

  • Design and implement biomarker assays in clinically relevant bio samples.

  • Make detailed observations, analyze data, interpret and clearly communicate results in a variety of settings.

  • Maintain timely and accurate lab records consistent with good documentation practices.

  • Significantly contribute to patent filings, diligence reports, primary research publications, and/or regulatory documents.

  • Participate in top conferences and academic partnerships in the primary research area.

  • Maintain excellent scientific expertise in primary research areas while expanding knowledge of related disciplines.

  • Can expect to spend up to 30% of their time in the lab.

Qualifications/Skills:

  • PhD is required with 10 years of industry and/or academic experience post-training.
  • Record of high-quality publications and/or public presentations focused on neurodegenerative disorders, neurobiology, translational research, and/or biomarkers.
  • Demonstrated expertise in the development, execution and interpretation of complex biomarker assays.
  • Excellent oral, presentation and written communication skills required.
  • Creative thinker with a strong sense of responsibility and a collaborative spirit.
  • Outstanding time management skills across multiple projects.

Salary Range: $165,333.00 to $204,000.00 .  Compensation for the role will depend on a number of factors, including a candidate’s qualifications, skills, competencies, and experience. Denali offers a competitive total rewards package, which includes a 401k, healthcare coverage, ESPP and a broad range of other benefits. Learn more at https://www.denalitherapeutics.com/careers

This compensation and benefits information is based on Denali’s good faith estimate as of the date of publication and may be modified in the future.This compensation and benefits information is based on Denali’s good faith estimate as of the date of publication and may be modified in the future.
 

Denali is committed to its core company value of unity by creating a diverse and inclusive environment. We are proud to be an equal opportunity employer and do not discriminate against any employee or applicant for employment because of race, color, sex, age, national origin, religion, sexual orientation, gender identity and/or expression, status as a veteran, basis of disability, or any other federal, state, or local protected class.

Salary : $165,333 - $204,000

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