What are the responsibilities and job description for the Scientist, Preclinical Translational Sciences position at Denali Therapeutics Inc?
Neurodegenerative diseases are one of the largest medical challenges of our time. Denali Therapeutics is a biotechnology company dedicated to developing breakthrough therapies for neurodegenerative diseases through our deep commitment to degeneration biology and principles of translational medicine. Denali is founded on the collaboration of leading scientists, industry experts, and investors who share the vision that scientific discovery energetically applied to translational medicine is the key to delivering effective therapies to patients.
We invite you to consider an opportunity with Denali to help achieve our goal of delivering meaningful therapeutics to patients.
The Opportunity
We are currently seeking a highly motivated, independent scientist to support in vivo work in our Preclinical Translational Sciences group. The primary function of this position is to identify and develop relevant animal models for biomarker discovery, assessment of target and biological pathway modulation, and establishing PK/PD relationship with Denali’s therapeutic candidates. This role will have a specific focus on the development and characterization of Parkinson’s disease rodent models to identify potential translatable biomarkers that can be used to support our therapeutic teams.
This role will need to work cross functionally as well as with colleagues within Discovery and Development Sciences to design, conduct, and provide strategic guidance to project teams. The Scientist role will be critical in generating data to support multiple research programs at Denali Therapeutics, ultimately contributing to the discovery and development of novel therapeutics for the treatment of neurodegenerative diseases.
Responsibilities (included but not limited to the following)
Develop and conduct hands-on experiments to characterize Parkinson’s disease rodent models utilizing techniques such as immunohistochemistry, microscopy, immunoassays, etc. and exploring novel endpoints relevant to Parkinson’s disease
Lead efforts and collaborate with cross functions (i.e. Discovery, Development Sciences, Translational Medicines) to identify robust and translatable target, pathway, and disease biomarkers in relevant animal models
Design, implement, and assist in acute and chronic animal studies to evaluate biological effects of therapeutic candidates
Serve on large molecule project teams throughout lead/candidate identification, IND-enabling, and Early Clinical Development phases to enable project decision making
Design and communicate experimental study designs and analyze, interpret, and present data and experimental conclusions to cross-functional teams
Support functional related goals within the Preclinical Translational Sciences team as needed
Requirements
PhD. in a relevant field (preferably neurobiology). Additional industry or postdoctoral experience is desirable but not required.
Proficiency in designing and implementing in vivo studies with experience in rodent handling, dosing, and tissue / fluid collection; stereotaxic experience preferred.
Preferred hands-on experience with Parkinson’s disease rodent models.
Experience in biochemical, molecular and cellular techniques (i.e. plate based immunoassays, FACs, immunohistochemistry).
Ability to think strategically and work effectively in a fast-paced environment with excellent time management skills, strong scientific rigor, and attention to detail.
Excellent interpersonal and communication skills as well as the ability to work effectively as part of a cross functional team.
This compensation and benefits information is based on Denali’s good faith estimate as of the date of publication and may be modified in the future.This compensation and benefits information is based on Denali’s good faith estimate as of the date of publication and may be modified in the future.
Denali is committed to its core company value of unity by creating a diverse and inclusive environment. We are proud to be an equal opportunity employer and do not discriminate against any employee or applicant for employment because of race, color, sex, age, national origin, religion, sexual orientation, gender identity and/or expression, status as a veteran, basis of disability, or any other federal, state, or local protected class.
Salary : $123,000 - $158,000
