Scientist, Purification Process Development

Neurodegenerative diseases are one of the largest medical challenges of our time. Denali Therapeutics is a biotechnology company dedicated to developing breakthrough therapies for neurodegenerative diseases through our deep commitment to degeneration biology and principles of translational medicine. Denali is founded on the collaboration of leading scientists, industry experts, and investors who share the vision that scientific discovery energetically applied to translational medicine is the key to delivering effective therapies to patients.

We invite you to consider an opportunity with Denali to help achieve our goal of delivering meaningful therapeutics to patients.

This position is responsible for developing efficient, robust and scalable purification processes to support our large molecule pipeline.

Key Accountabilities/Core Job Responsibilities:

• Design and execute lab-scale chromatography and filtration studies to inform and support large scale process decisions

• Maintain existing workflows to provide purification support for cell line and cell culture development activities

• Develop purification processes to support early and late-stage clinical production

• Execute methods for in-process testing using ELISA, HPLC, UV and SDS-PAGE based analytics

• Transfer purification processes to clinical manufacturing sites and support ongoing manufacturing campaigns as needed

• Author process descriptions, development reports, tech transfer documents and relevant IND sections

• Work closely with discovery groups and project teams to transfer process/molecule knowledge into development

Qualifications/Skills:

• PhD in Biology, Biochemistry, Chemical Engineering, or related scientific discipline with 0-5 years of purification process development experience in academia/industry or BS or MS with 5 years of industry experience

• Experience developing protein purification processes to support early or late-stage clinical production

• Experience with late-stage process characterization and validation is a plus

• Proven track record of representing bioprocess functions in cross-functional teams and working effectively with CMOs

• Knowledge of process virology, including working with contract labs to plan and execute viral clearance studies is desired

• Broad experience in protein characterization, multivariate experimentation and analytical techniques

• Expertise in AKTA protein purification, tangential and normal flow filter sizing

• Excellent critical thinking, scientific problem-solving and communication skills

Salary Range: $125,000.00 to $157,000.00 .  Compensation for the role will depend on a number of factors, including a candidate’s qualifications, skills, competencies, and experience. Denali offers a competitive total rewards package, which includes a 401k, healthcare coverage, ESPP and a broad range of other benefits. Learn more at https://www.denalitherapeutics.com/careers

This compensation and benefits information is based on Denali’s good faith estimate as of the date of publication and may be modified in the future.This compensation and benefits information is based on Denali’s good faith estimate as of the date of publication and may be modified in the future.
 

Denali is committed to its core company value of unity by creating a diverse and inclusive environment. We are proud to be an equal opportunity employer and do not discriminate against any employee or applicant for employment because of race, color, sex, age, national origin, religion, sexual orientation, gender identity and/or expression, status as a veteran, basis of disability, or any other federal, state, or local protected class.

Salary : $125,000 - $157,000