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ETV Account Lead (Mid-Atlantic - Philadelphia)

Denali Therapeutics
South San Francisco, CA Full Time
POSTED ON 4/17/2025
AVAILABLE BEFORE 6/14/2025

Neurodegenerative diseases are one of the largest medical challenges of our time. Denali Therapeutics is a biotechnology company dedicated to developing breakthrough therapies for neurodegenerative diseases through our deep commitment to degeneration biology and principles of translational medicine. Denali is founded on the collaboration of leading scientists, industry experts, and investors who share the vision that scientific discovery energetically applied to translational medicine is the key to delivering effective therapies to patients.

We invite you to consider an opportunity with Denali to help achieve our goal of delivering meaningful therapeutics to patients.

Neurodegenerative diseases are one of the largest medical challenges of our time. Denali Therapeutics is a biotechnology company dedicated to developing breakthrough therapies for neurodegenerative diseases through our deep commitment to degeneration biology and principles of translational medicine. Denali is founded on the collaboration of leading scientists, industry experts, and investors who share the vision that scientific discovery energetically applied to translational medicine is the key to delivering effective therapies to patients. As our discovery and development efforts have matured, we are preparing to launch our first asset in Hunter syndrome, and we invite you to consider an opportunity with Denali to help achieve our goal of delivering meaningful therapeutics to patients.




The Enzyme Transport Vehicle (ETV) Account Lead role is a field-based role reporting to a Senior Regional Sales Director and is responsible for building and maintaining long term relationships with physicians and other customers to maximize the impact of our innovative portfolio in the Lysosomal Storage Disorder communities we serve. The ETV Account Lead role is empowered to deliver both access and reimbursement support to the accounts within their assigned territory and deliver promotional messages to support and inform product adoption in a compliant manner. This role will be the single accountable individual within their territory representing Denali in educating the MPS II Hunter syndrome community and customers on the approved use of tividenofusp alfa following FDA approval.

Key Accountabilities/Core Job Responsibilities:


The ETV Account Lead plays a central role in our cross functional field team, or Local Care Team, and the successful candidate will have a deep understanding of both their local healthcare market and of the MPS II disease state. To successfully deliver our innovative ETV asset to the MPS II community, establishing trust and collaborating compliantly across Denali’s team is essential in order to urgently address the needs of our customers and deliver on Denali’s goals. The Account Lead will be responsible for delivering on Denali’s business objectives through strategic account plan execution and agility in adapting to each unique customer’s needs.


Market and MPS II Knowledge:

  • Profile accounts to gather insights, understand HCO decision making, and inform marketing and targeting strategies

  • Identify and track potential HCPs treating MPS II patients to understand specific drivers, barriers, and opportunities to support these customers

Account Planning:

  • Collaborate with peers, Local Care Team members, and field leadership to develop and execute strategic account plans which align to business strategy and deliver an exceptional customer experience

  • Build and adjust tactical plans that meet our customers’ needs and deliver on our brand strategy and business objectives, collaboratively with field and brand leadership

  • Develop a launch day engagement plan to deliver tailored strategies and tactics for HCO readiness

  • Establish a post-launch call plan, including customer visit schedules aligned to territory and account plans

Customer Engagement:

  • Communicate disease state awareness and education to elevate the urgency to appropriately treat MPS II

  • Compliantly educate HCPs and MPS II multidisciplinary care team members on tividenofusp alfa efficacy, safety, and dosing through approved materials and messaging

  • Compliantly educate HCPs and office staff on tividenofusp alfa access process and associated payer policies

  • Educate on Denali’s patient support services and offerings

  • Partner with all Denali field roles to deliver an exceptional customer experience through a solution-oriented mindset which prioritizes the Hunter syndrome patient and family experience

  • Participate in conferences, scientific meetings, and community events to engage with and educate HCPs on MPS II disease state and tividenofusp alfa post launch

Denali Engagement:

  • Participate in field meetings and training programs to understand disease state, brand strategy messaging and objectives, and payer landscape, policies and reimbursement trends

  • Timely completion of all corporate, compliance and HCP engagement policy training to ensure appropriate customer interactions and alignment with Denali values

  • Collaborate compliantly with peers and Local Care Team field members

  • Appropriately share insights and learnings with leadership, marketing, insights and operations to contribute to evolving strategy

Qualifications/Skills:

  • Bachelor’s Degree with 7 years of relevant experience or Master’s Degree and 5 years of relevant experience

  • 5 Years of customer-facing experience

  • Rare disease experience; MPS experience preferred

  • Track record of successful launch experience, and proven track record for meeting or exceeding targets

  • Reimbursement and access education and support experience

  • Fluency in healthcare ecosystem and payer knowledge

  • Highly collaborative and self-driven mindset

  • Passion for patients and mission-driven work

  • Excellent communication and analytical skills

Salary Range: $0.00 to $0.00 . Compensation for the role will depend on a number of factors, including a candidate’s qualifications, skills, competencies, and experience. Denali offers a competitive total rewards package, which includes a 401k, healthcare coverage, ESPP and a broad range of other benefits. Learn more at https://www.denalitherapeutics.com/careers

This compensation and benefits information is based on Denali’s good faith estimate as of the date of publication and may be modified in the future.This compensation and benefits information is based on Denali’s good faith estimate as of the date of publication and may be modified in the future.


Denali is committed to its core company value of unity by creating a diverse and inclusive environment. We are proud to be an equal opportunity employer and do not discriminate against any employee or applicant for employment because of race, color, sex, age, national origin, religion, sexual orientation, gender identity and/or expression, status as a veteran, basis of disability, or any other federal, state, or local protected class.

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