Principal Scientist, Protein Engineering

Company Overview:

Dyne Therapeutics is discovering and advancing innovative life-transforming therapeutics for people living with genetically driven neuromuscular diseases. Leveraging the modularity of its FORCE™ platform, Dyne is developing targeted therapeutics that deliver to muscle and the central nervous system (CNS). Dyne has a broad pipeline for neuromuscular diseases, including clinical programs for myotonic dystrophy type 1 (DM1) and Duchenne muscular dystrophy (DMD) and preclinical programs for facioscapulohumeral muscular dystrophy (FSHD) and Pompe disease. For more information, please visit https://www.dyne-tx.com/, and follow us on X, LinkedIn and Facebook. 

Role Summary:

Dyne is seeking a Principal Scientist in protein engineering to drive new therapeutic molecules for rare genetic diseases. Responsibilities include designing, discovering, and producing candidate molecules, such as antibodies and fusion proteins.

The candidate will support and lead drug discovery projects, working closely with chemists, biochemists, and analytical scientists, as well as disease biologists and pharmacologists. The ideal candidate is innovative, collaborative, and an ambitious self-starter with exceptional communication skills. This role offers the opportunity to contribute to and expand Dyne's platform technology, advancing life-transforming therapies for neuromuscular diseases

This role is based in Waltham, MA without the possibility of being remote.

Primary Responsibilities Include:

• Design antibodies, antibody fragments, and antibody fusion proteins to serve as standalone therapeutics or integrate with Dyne’s proprietary delivery platform
• Oversee production and rigorous biochemical & biophysical characterization of therapeutic protein candidates
• Hands-on experimental design, execution, and data analysis of studies to drive go/no go decisions as needed
• Contribute to the discussions and planning of multiple cross-functional projects in either a supporting and/or leadership role
• Work effectively with other disciplines including biochemistry, disease biology, and safety/toxicology to generate and communicate preclinical data in support of therapeutic development
• Prepare reports, protocols, and other documentation to support clinical development and manufacturing of lead therapeutic candidates
• Provide mentorship to junior scientists in the Platform Development group
• Manage external vendors to supply materials, analyze reagents, etc
• Contribute to building a positive, team-oriented culture

Education and Skills Requirements:

• PhD in Biochemistry, Molecular Biology or related scientific/engineering discipline and 6 years of hands-on experience; or BSc/MSc with 8 years of relevant industry experience is required.
• Deep hands-on experience with antibody discovery (display technology or hybridoma) and/or engineering (including affinity maturation, Fc engineering, and related aspects), and protein engineering across other scaffolds.
• Extensive experience with protein production and purification across different expression hosts and modalities, including early stage cell line development and/or technology transfer to external manufacturing partners.
• Strong hands-on experience with analytical and biophysical protein characterization techniques (SDS-PAGE, SEC, LC-MS, etc.)
• Experience contributing to cross-functional drug discovery teams bringing candidate therapeutics from early discovery to IND, including stage-appropriate developability assessments.
• Experience with antibody-drug conjugates, oligonucleotide conjugates, and/or enzyme replacement therapeutics is a plus.
• Project leadership experience is a plus.
• Strong track record of scientific accomplishments with relevant publications and presentations.
• Ability to critically evaluate, summarize, and interpret data
• Understand published scientific literature outside of their immediate area of expertise and apply this understanding to drive innovation
• Strong written and oral communication skills, organization, and multitasking, and working in a highly collaborative and cross-functional research environment.

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The statements contained herein reflect general details as necessary to describe the principles functions for this job, the level of knowledge and skill typically required, and the scope of responsibility, but should not be considered an all-inclusive listing of work requirements.  Individuals may perform other duties as assigned, including work in other functional areas to cover absences or relief, to equalize peak work periods or otherwise balance workload.

This description is not intended to be constructed as an exhaustive list of duties, responsibilities, or requirements for the position. This position may change or assume additional duties at any time.  The employee may be requested to perform different or additional duties as assigned. All Employees are expected to adhere to all company policies and act as a role model for company values.

Dyne Therapeutics is an equal opportunity employer and will not discriminate against any employee or applicant on the basis of age, color, disability, gender, national origin, race, religion, sexual orientation, veteran status, or any classification protected by federal, state, or local law.