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Director of Vector Production

Dyno Therapeutics
Watertown, MA Full Time
POSTED ON 2/4/2025
AVAILABLE BEFORE 3/4/2025

Associate Director - Vector Production

A seasoned leader is sought after to spearhead Dyno Therapeutics' AAV production endeavors. This individual will play a pivotal role in optimizing and scaling processes to meet organizational goals.

Responsibilities:

  • Lead the end-to-end vector production process, ensuring alignment with strategic objectives and timelines.
  • Analyze run/batch summaries to inform production decisions and optimize process performance.
  • Develop a strategy to ensure Dyno's vector production capabilities align with the organization's broader capsid engineering strategy.
  • Mentor and develop a high-performing team, including direct reports.
  • Collaborate to drive process optimization across upstream (suspension culture or adherent bioreactors) and downstream (depth filtration, TFF, FPLC) processes.

Requirements:

  • Master's or Ph.D. in bioprocessing, chemical engineering, vector biology, or biological sciences.
  • 8-10 years of experience in the biotechnology or pharma industry or 5 years of relevant experience in AAV manufacturing.
  • Experience running end-to-end vector production processes at scale, either in suspension culture at 50 L or medium/large-scale adherent bioreactors.
  • Proven expertise managing upstream (stir-tanks/rockers if in suspension) and downstream (depth filtration, TFF, FPLC, fill/finish) processes of AAV production.
  • Well-developed background in process optimization.
  • Experience leading a team of at least three direct reports.

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