What are the responsibilities and job description for the Scientist/Senior Scientist, Protein Engineering position at Ensoma?
Scientist / Senior Scientist, Protein Engineering
We are seeking a highly motivated and skilled Scientist / Senior Scientist to join our Protein Engineering team in Boston as we develop innovative antibody-drug conjugates (ADCs) for treating diseases with unmet medical needs. This position is ideal for a candidate with a passion for cutting-edge biochemistry and a desire to make a significant impact in the in vivo gene therapy space leveraging expertise in ADC and therapeutic protein engineering fields.
As part of a growing team, you will have the opportunity to work alongside experienced researchers and develop your skills in protein conjugation, antibody engineering, and cell-based assay development. You will also collaborate with colleagues across the in vivo biology and genome editing teams, as well as CROs. This is an exciting opportunity for someone who has a strong scientific and technical background and hands-on experience to continue building upon this foundation in a high-impact role.
Responsibilities :
- Lead efforts in antibody and protein engineering for ADC development.
- Design, execute, and optimize conjugation strategies for linking payloads to antibodies or proteins.
- Develop and troubleshoot cell-based assays to evaluate ADC potency and efficacy.
- Interface with CROs and external partners to oversee outsourced workstreams, ensuring high-quality data generation.
- Interpret experimental data, integrate findings with current scientific literature, and propose innovative solutions for ADC optimization.
- Present findings to internal teams, multidisciplinary research groups, and at external meetings or conferences when appropriate.
- Provide guidance and mentorship to junior scientists and research associates, fostering a collaborative research environment.
- Identify and escalate technical challenges, incorporating feedback to optimize research outcomes.
Qualifications : Required :
Preferred :
About Ensoma :
Ensoma is a place where you can ask the big questions. We look at gene therapy today and ask : What if we could eliminate the patient burden? What if we could treat diseases that affect millions? What if we could treat people anywhere around the world?
Ensoma was founded to answer these questions. Our platform is the most advanced in vivo hematopoietic stem cell (HSC) engineering technology. It combines an off-the-shelf, in vivo delivery system with an advanced gene engineering toolkit. Through its HSC engineering platform, Ensoma can selectively and durably modify any cells of the entire hematopoietic system to treat diseases with unprecedented versatility - all with a one-time therapy. We believe the future of medicine lies within us - and this bigger, bolder vision for gene therapy needs incredible people to make it a reality.
For our team, realizing this vision is personal. Founded and guided by leaders drawn from the top of the cell, gene therapy and gene editing field, we feel an urgency and passion for our work driven by its potential global impact.
A meeting at Ensoma is a space where curiosity, trust, authenticity, problem-solving and professional development are celebrated. A career at Ensoma is an opportunity to be part of the team building the future of medicine.
Ensoma is a 5AM Portfolio company supported by top-tier investors, strategic partners, and a passionate team committed to a bold global vision for genomic medicines. Ensoma is headquartered in Boston, Massachusetts. For more information, please visit www.ensoma.com.
