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Senior Associate Scientist, in vivo Biology

Ensoma
Boston, MA Full Time
POSTED ON 2/25/2025
AVAILABLE BEFORE 5/24/2025

Senior Associate Scientist, in vivo Biology

We are seeking an independent and highly motivated Senior Associate Scientist to join our research and development team to conduct complex studies using animal models and ex vivo sample analysis to support development of novel therapeutics. You will utilize your strong in vivo technical skills and solid understanding of disease animal models in hematology / immunology field to help execute a wide variety of projects across Ensoma's portfolio.

You will join a team of scientists dedicated to moving a novel gene therapy drug candidate into the clinic. Join us and be part of building a company revolutionizing the reach and access of the curative power of genomic medicines for patients with serious diseases.

Responsibilities :

  • Conduct complex in vivo experiments using disease and immunocompromised mouse models
  • Perform primary cell isolation and culture
  • Execute in vitro and ex vivo cell-based assays
  • Manage internal and external mouse colonies
  • Analyze data and present results at group meetings and conferences
  • Contribute to publications and written reports for regulatory filings
  • Maintain laboratory equipment and rooms as required

Qualifications : Required :

  • A Bachelor's Degree in a biological science with a minimum of six years or a Master's Degree with a minimum of three years of academic and / or industry experience
  • Experience in rodent handling dosing such as intravenous (IV), intraperitoneal (IP), intramuscular (IM), or subcutaneous (SC) and tissue collection, particularly of hemato-lymphoid organs (bone marrow, spleen, blood)
  • Demonstrated experience in performing primary cell cultures, hematopoietic stem cell and / or immune cell based in vitro and in vivo assays (bone marrow transplantation)
  • Experience with multi-color flow cytometry and ability to operate flow cytometers independently
  • Ability to design experiments and troubleshoot technical hurdles independently
  • Preferred :

  • Demonstrated experience in erythroid cell biology
  • Experience in gene therapy
  • About Ensoma :

    Ensoma is a place where you can ask the big questions. We look at gene therapy today and ask : What if we could eliminate the patient burden? What if we could treat diseases that affect millions? What if we could treat people anywhere around the world?

    Ensoma was founded to answer these questions. Our platform is the most advanced in vivo hematopoietic stem cell (HSC) engineering technology. It combines an off-the-shelf, in vivo delivery system with an advanced gene engineering toolkit. Through its HSC engineering platform, Ensoma can selectively and durably modify any cells of the entire hematopoietic system to treat diseases with unprecedented versatility - all with a one-time therapy. We believe the future of medicine lies within us - and this bigger, bolder vision for gene therapy needs incredible people to make it a reality.

    For our team, realizing this vision is personal. Founded and guided by leaders drawn from the top of the cell, gene therapy and gene editing field, we feel an urgency and passion for our work driven by its potential global impact.

    A meeting at Ensoma is a space where curiosity, trust, authenticity, problem-solving and professional development are celebrated. A career at Ensoma is an opportunity to be part of the team building the future of medicine.

    Ensoma is a 5AM Portfolio company supported by top-tier investors, strategic partners, and a passionate team committed to a bold global vision for genomic medicines. Ensoma is headquartered in Boston, Massachusetts. For more information, please visit www.ensoma.com.

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