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Senior Research Associate / Associate Scientist - Downstream Process Development

EPM Scientific
South San Francisco, CA Full Time
POSTED ON 3/27/2025
AVAILABLE BEFORE 4/25/2025

Client

Our client is an emerging gene editing company targeting RNA.

Job Summary :

We are looking for an experienced AAV Production Senior Research Associate / Associate Scientist to join our team. This role focuses on leading AAV production, optimizing downstream processes to improve yield, quality, and consistency. The ideal candidate will have extensive experience in AAV production using both adherent and suspension cell platforms and a proven ability to optimize protocols for scale-up and purification. Collaboration and teamwork are essential for this role.

Key Responsibilities :

AAV Production and Process Development :

  • Develop and scale AAV production processes, including gradient and affinity column purification.
  • Perform cell culture for AAV production (adherent and suspension).
  • Operate bioreactors, AKTA systems, and automated buffer exchange systems.
  • Improve purification methods to streamline workflows.

AAV Characterization and Assay Development :

  • Conduct assays to evaluate AAV performance in mammalian cell lines.
  • Perform ddPCR, sequencing, and ELISA-based assays for AAV characterization.
  • Analyze AAV stability, aggregation, and particle-to-infectivity ratios.
  • Optimize purification and buffer exchange protocols.
  • Inventory, Documentation, and Workflow Management :

  • Manage lab inventory and ensure efficient use of resources.
  • Maintain accurate records and author SOPs and production batch records.
  • Produce AAV lots for research and preclinical studies.
  • Collaboration and Training :

  • Train and guide team members in AAV production techniques.
  • Support viral transduction for in vitro and in vivo applications.
  • Collaborate with cross-functional teams to meet project goals.
  • Lead troubleshooting efforts and ensure protocol compliance.
  • Qualifications :

  • Education : Bachelor's or Master's in Molecular Biology, Biochemistry, Virology, or a related field, or equivalent experience.
  • Experience : 4 years of hands-on industry experience in AAV production, with expertise in both adherent and suspension HEK293 cells. Proven track record in scale-up production and purification processes.
  • Technical Skills : Proficiency with AKTA, bioreactors, and molecular biology techniques (e.g., DNA / RNA / protein isolation, cDNA synthesis, RT-PCR, qPCR, digital PCR, western blot, immunofluorescence).
  • Leadership : Ability to manage and mentor team members in a production environment.
  • Analytical Skills : Strong troubleshooting and optimization skills for viral vector production.
  • Compensation : $115,000-$130,000 base salary, depending on years of experience.

    Salary : $115,000 - $130,000

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