Director of In Vivo Biology

Company Description:
Evercrisp Biosciences, founded by world-renowned scientists with expertise in cutting-edge proprietary technologies, operates in stealth mode with substantial Series A backing from Apple Tree Partners (ATP). Evercrisp is focused on tackling genetically validated, “difficult-to-drug” targets, particularly in areas of high unmet need where genomic medicines can create transformative outcomes. At Evercrisp, innovation, collaboration, and a deep commitment to advancing human health drive our mission to develop first-in-class therapeutics.

Position Summary:
We are seeking a Director of In Vivo Biology to lead and design all in vivo studies at Evercrisp. This role is critical to advancing our receptor-targeted genetic medicine platform and preclinical pipeline programs. The successful candidate will oversee the In Vivo Biology team, comprising scientists and research associates, while collaborating with leaders across all departments. This individual will also develop innovative disease models to support Proof-of-Concept and IND-enabling studies and leverage a strong background in genetic diseases across multiple therapeutic areas.

Key Responsibilities:

• Strategic Leadership: Design, oversee, and execute all in vivo studies to advance Evercrisp’s platform development and pipeline programs.
• Disease Model Development: Build and refine disease models tailored to support preclinical evaluations and IND-enabling studies.
• Biomarker Assay Development: Develop and validate translatable biomarker assays to enable robust efficacy and pharmacodynamic readouts in preclinical studies.
• Team Leadership: Build, mentor, and lead the In Vivo Biology team, fostering a collaborative and innovative culture.
• Cross-functional Collaboration: Partner with the heads of computational, protein sciences, chemistry, cell biology, and other teams to align in vivo strategies with company objectives.
• Study Design and Execution: Develop robust preclinical study designs to evaluate the safety, efficacy, and pharmacokinetics/pharmacodynamics (PK/PD) of targeted genetic medicines.
• Data Analysis and Reporting: Analyze and communicate in vivo data to internal teams, external collaborators, and stakeholders.
• Platform Development: Provide critical insights to drive iterative improvements to Evercrisp’s targeted delivery platform.
• Regulatory Contributions: Support IND-enabling studies by generating high-quality preclinical data packages for regulatory filings.

Qualifications:

• Education: PhD in Pharmacology, Biology, or a related field with a focus on in vivo biology; advanced degree preferred.
• Experience: 8 years of relevant industry experience in in vivo biology or preclinical development, with at least 3 years in a leadership role.
• Technical Expertise: Strong expertise in in vivo models, PK/PD assessment, and genetic medicine delivery technologies (e.g., CRISPR, ASOs, siRNAs, or biologics).
• Disease Modeling: Proven track record in developing and applying disease models for genetic diseases across multiple therapeutic areas.
• Leadership: Proven ability to lead and manage scientific teams, fostering growth and collaboration.
• Collaboration: Demonstrated experience in cross-functional teamwork with protein scientists, bioinformaticians, and translational biologists.
• Communication: Exceptional ability to communicate complex scientific concepts clearly and effectively to diverse audiences.

Why Join Evercrisp?
At Evercrisp Biosciences, you will have the opportunity to lead groundbreaking work in computationally designed protein therapeutics, collaborate with world-class scientists, and make a significant impact on the lives of patients. Join us to help shape the future of genetic medicine.